Products Sirolimus (rapamycin) is commercially available as coated tablets and as an oral solution (Rapamune). It has been approved in many countries since 2000. Structure and properties Sirolimus (C51H79NO13, Mr = 914.2 g/mol) is a large, lipophilic and complex molecule. It is a macrocyclic lactone extracted from. This fungus was originally identified in a soil … Sirolimus (Rapamycin)
Products Sitagliptin is commercially available in film-coated tablet form as a monopreparation (Januvia) and as a fixed combination with metformin (Janumet, Janumet XR). It was approved in many countries in 2007 as the first representative of the gliptins. The combination with simvastatin is not yet registered in many countries (Juvisync). Generics were approved in 2018. … Sitagliptin
Products Lifitegrast was approved in the United States in 2016 and in many countries in December 2018 as single-dose eye drops (Xiidra, pronounced Saidra in English). Structure and properties Lifitegrast (C29H24Cl2N2O7S, Mr = 615.5 g/mol) is a tetrahydroisoquinoline derivative. It exists as a white powder that is soluble in water. Effects Lifitegrast (ATC S01XA25) has … Lifitegrast
P-glycoprotein P-glycoprotein (P-gp, MDR1) is a primary active efflux transporter with a molecular weight of 170 kDa, belonging to the ABC superfamily and consisting of 1280 amino acids. P-gp is the product of the -gene (formerly: ). P is for , ABC is for . Occurrence P-glycoprotein is found on various tissues of the human … P-Glycoprotein
