Products Enoxaparin is commercially available as a solution for injection (Clexane). It has been approved in many countries since 1988. Biosimilars were released in the EU in 2016 and in many countries in 2020 (Inhixa). Structure and properties Enoxaparin is present in the drug as enoxaparin sodium, the sodium salt of a low-molecular-weight heparin (LMWH) … Enoxaparin
Effects Antithrombotic Anticoagulant Fibrinolytic Active ingredients Salicylates: Acetylsalicylic acid 100 mg (Aspirin Cardio). P2Y12 antagonists: Clopidogrel (Plavix, generics). Prasugrel (Efient) Ticagrelor (Brilique) GP IIb/IIIa antagonists: Abciximab (ReoPro) Eptifibatide (Integrilin) Tirofiban (Aggrastat) PAR-1 antagonists: Vorapaxar (Zontivity) Vitamin K antagonists (coumarins): Phenprocoumon (Marcoumar). Acenocoumarol (Sintrom) Not on sale in many countries: dicoumarol, warfarin. Heparins: Heparin sodium Heparin-Calcium … Antithrombotics
Products Low-molecular-weight heparins are commercially available as injectable solutions, in the form of prefilled syringes, ampoules, and lancing ampoules. The active ingredients now commonly used in many countries were first approved in the late 1980s. Biosimilars are available in some countries. The active ingredients are abbreviated in English with the acronym LMWH (low molecular weight … Low-Molecular-Weight Heparins
Products Apixaban has been approved in many countries since 2011 in the form of film-coated tablets (Eliquis). Structure and properties Apixaban (C25H25N5O4, Mr = 460.0 g/mol) was developed starting from razaxaban. It is an oxopiperidine and pyrazole derivative. Effects Apixaban (ATC B01AF02) has antithrombotic properties. It is an oral, direct, potent, selective, and reversible inhibitor … Apixaban
Symptoms The possible symptoms and signs of deep vein thrombosis include: Pain or cramping in the legs Swelling (edema), feeling of tension Warmth sensation, overheating Reddish to blue-purple discoloration of the skin Increased visibility of the superficial veins The symptoms are rather nonspecific. Deep vein thrombosis may also be asymptomatic and discovered by chance. A … Deep Vein Thrombosis
Definition When people talk about “Clexane 40®”, they usually mean a pre-filled heparin syringe containing 4000 IU (international units). This corresponds to 40 mg enoxaparin sodium of the active ingredient enoxaparin . “Clexane 40®” is the trade name of this drug. The drug is dissolved in a defined volume of 0.4ml. In addition to this … Clexane 40
Storage The ready-to-use syringes can be stored at room temperature (not higher than 25°C) until the expiry date. Special care should be taken to ensure that children do not have access to medication. Side effects Bleeding: If severe bleeding occurs during therapy with heparin, the heparin effect can be reversed in an emergency by administration … Storage | Clexane 40
Products Biosimilars are copycat preparations of biotechnology-derived drugs (biologics) that have strong similarities to the originator drugs but that are not exactly the same. The similarity relates to biological activity, structure, function, purity and safety, among other things. Biosimilars differ from generics of small molecule drugs in important ways. Biosimilars are usually marketed as injection … Biosimilars
Symptoms Deep vein thrombosis develops as a result of a blood clot in the deep veins. Typical symptoms are: Painful and swollen legs and calves, edema. Redness and discoloration of the skin Locally increased temperature Often asymptomatic It poses a significant risk for the development of pulmonary embolism when part of the thrombus breaks loose … Air Travel Thrombosis
Symptoms Possible symptoms of pulmonary embolism include: Shortness of breath (dyspnea), rapid breathing, cyanosis. Chest pain Cough with blood or sputum Rapid heartbeat Fever, sweating Loss of consciousness (syncope) Low blood pressure, shock Symptoms of deep vein thrombosis, such as a swollen, warm leg The severity varies and depends, among other things, on how large … Pulmonary Embolism Causes and Treatment
