enzymes

What happens in Alpha-1-antitrypsin deficiency? | Alpha-1-antitrypsin

What happens in Alpha-1-antitrypsin deficiency? Alpha-1-antitrypsin works through two different systems. – One is the adhesion of the defective alpha-1-antitrypsin to the site of origin. The defective protein accumulates in the liver and the liver can no longer adequately perform its other tasks. In newborns, this can lead to severe liver damage, cirrhosis of the … What happens in Alpha-1-antitrypsin deficiency? | Alpha-1-antitrypsin

Consequences of an altered antitrypsin level | Alpha-1-antitrypsin

Consequences of an altered antitrypsin level The increase in alpha-1-antitrypsin itself has hardly any negative consequences for the body and is a normal reaction to abnormal processes in the body. The change in value is therefore an indication of possibly pathological processes in the body, which in turn lead to symptoms of illness. In this … Consequences of an altered antitrypsin level | Alpha-1-antitrypsin

The tyrosine kinase

What is a tyrosine kinase? Tyrosine kinase is a specific group of enzymes that are functionally assigned to protein kinases in a biochemical sense. Protein kinases reversibly (possibility of back-reaction) transfer phosphate groups to the OH group (hydroxy group) of the amino acid tyrosine. The phosphate group is transferred to the hydroxy group of the … The tyrosine kinase

What is the tyrosine kinase receptor? | The tyrosine kinase

What is the tyrosine kinase receptor? The tyrosine kinase receptor represents a membrane-bound receptor, i.e. a receptor anchored in the cell membrane. Structurally, it is a receptor with a transmembrane complex. This means that the receptor passes through the entire cell membrane and also has an extra- and intracellular side. On the extracellular side, the … What is the tyrosine kinase receptor? | The tyrosine kinase

For which indications are they used? | The tyrosine kinase

For which indications are they used? Tyrosine kinase inhibitors are used for various malignant diseases. Imatinib is used in particular in chronic myeloid leukemia. Further applications are non-small cell lung cancer (NSCLC), breast cancer and colon cancer. Due to the highly selective attack mechanism of tyrosine kinase inhibitors, they are generally better tolerated than conventional … For which indications are they used? | The tyrosine kinase