Products Reteplase was marketed as an injectable (Rapilysin). The drug was approved in many countries in 1996 and withdrawn from the market in 2013. Structure and properties Reteplase is derivative of tissue-specific plasminogen activator (t-PA). It is a serine protease containing 355 of the 527 amino acids of native t-PA. The protein is produced by … Reteplase
Symptoms The possible symptoms of a transient ischemic attack (TIA) include: Visual disturbances, temporary blindness Difficulty swallowing Sensory disturbances such as numbness or formication. Speech disorders Coordination disorders, loss of balance, paralysis. Behavioral disturbances, fatigue, drowsiness, agitation, psychosis, memory impairment. The symptoms occur suddenly, are transient and last only briefly, during a maximum of one … Transient Ischemic Attack
Effects Antithrombotic Anticoagulant Fibrinolytic Active ingredients Salicylates: Acetylsalicylic acid 100 mg (Aspirin Cardio). P2Y12 antagonists: Clopidogrel (Plavix, generics). Prasugrel (Efient) Ticagrelor (Brilique) GP IIb/IIIa antagonists: Abciximab (ReoPro) Eptifibatide (Integrilin) Tirofiban (Aggrastat) PAR-1 antagonists: Vorapaxar (Zontivity) Vitamin K antagonists (coumarins): Phenprocoumon (Marcoumar). Acenocoumarol (Sintrom) Not on sale in many countries: dicoumarol, warfarin. Heparins: Heparin sodium Heparin-Calcium … Antithrombotics
Products Streptokinase was commercially available as an injectable in many countries (Streptase, off label). It is still available in other countries. Structure and properties Streptokinase is a protein derived from group C hemolytic streptococci. Effects Streptokinase (ATC B01AD01) has fibrinolytic and thrombolytic properties. It combines with plasminogen to form a streptokinase-plasminogen complex. This complex converts … Streptokinase
Effects Fibrinolytic: dissolve fibrin Thrombolytic: dissolve thrombi Indications For the treatment of thrombosis and embolism: Myocardial infarction Ischemic stroke Deep vein thrombosis Pulmonary embolism Acute and subacute thrombosis Arterial occlusive diseases Agents Alteplase (Actilyse) Urokinase (Urokinase HS medac) Reteplase (Rapilysin, out of trade) Streptokinase (streptase, out of trade) Tenecteplase (metalysis)
Products Alteplase is commercially available as an injectable (Actilyse). The drug has been approved in many countries since 1988. Structure and properties Alteplase is a recombinant tissue plasminogen activator (rt-PA) produced by biotechnological methods. It is a serine protease composed of 527 amino acids. Effects Alteplase (ATC B01AD02) has fibrinolytic and thrombolytic properties. The enzyme … Alteplase
Symptoms A heart attack manifests itself in acute and severe pain and a feeling of tightness and pressure in the chest, which may also radiate to the arms, jaw or abdomen. Other symptoms include nausea, indigestion, shortness of breath, coughing, a break of sweat, pallor, fear of death, unconsciousness and dizziness. A myocardial infarction lasts … Heart Attack Causes and Treatment
Symptoms The possible symptoms and signs of deep vein thrombosis include: Pain or cramping in the legs Swelling (edema), feeling of tension Warmth sensation, overheating Reddish to blue-purple discoloration of the skin Increased visibility of the superficial veins The symptoms are rather nonspecific. Deep vein thrombosis may also be asymptomatic and discovered by chance. A … Deep Vein Thrombosis
Products Urokinase is commercially available as a powder for the preparation of a solution for injection or infusion (Urokinase HS medac). The drug has been approved in many countries since 1988. Structure and properties Urokinase is a serine protease, which is extracted from human urine in China. It is also possible to produce it using … Urokinase
Symptoms Possible symptoms of pulmonary embolism include: Shortness of breath (dyspnea), rapid breathing, cyanosis. Chest pain Cough with blood or sputum Rapid heartbeat Fever, sweating Loss of consciousness (syncope) Low blood pressure, shock Symptoms of deep vein thrombosis, such as a swollen, warm leg The severity varies and depends, among other things, on how large … Pulmonary Embolism Causes and Treatment
Products Tenecteplase is commercially available as an injectable (metalysis). The drug has been approved in many countries since 2000. Structure and properties Tenecteplase is a recombinant fibrin-specific plasminogen activator produced by biotechnological methods. The glycoprotein consists of 527 amino acids. The sequence is modified from native tissue-specific plasminogen activator (t-PA) at three sites. Effects Tenecteplase … Tenecteplase
