How imatinib works As a so-called BCR-ABL kinase inhibitor, imatinib inhibits an enzyme that is overactive in cancer cells. The activity of this tyeosin kinase is thereby downregulated so that it again corresponds to that in healthy cells. Because healthy cells do not have this pathologically altered enzyme, imatinib only works on cancer cells. The … Imatinib: Effects, Applications, Side Effects
Products Dasatinib is commercially available in the form of film-coated tablets (Sprycel). It has been approved in many countries since 2007. Generic versions were registered in 2020. Structure and properties Dasatinib (C22H26ClN7O2S, Mr = 488.0 g/mol) exists as a white powder that is insoluble in water. It is an aminopyrimidine derivative. Effects Dasatinib (ATC L01XE06) … Dasatinib
Products Nilotinib is commercially available in capsule form (Tasigna). It has been approved in many countries since 2007. Structure and properties Nilotinib (C28H22F3N7O, Mr = 529.5 g/mol) is present in the drug product as nilotinib hydrochloride monohydrate, a white to slightly yellowish or greenish-yellow powder. The aminopyrimidine is structurally closely related to its precursor imatinib … Nilotinib
Background Kinases (phosphotransferases) are a large family of enzymes involved in the transduction and amplification of signals on and in cells. They exert their effects by phosphorylating their substrates, that is, by adding a phosphate group to the molecules (Figure). Kinases have complicated names that are usually abbreviated: ALK, AXL, BCR-ABL, c-Kit, c-Met, ERBB, EGFR, … Kinase Inhibitors
Symptoms Gray hair is caused by single to many white hairs in the hairstyle. Together with the normally pigmented hair, the hair appears gray to silver. Gray hair has an altered structure, stands crosswise and is less easy to comb. Hair has an important communication function and is important for external appearance and attractiveness. Full … Gray Hair
Definition and examples When a drug is administered, for example, a tablet is swallowed or an injection is injected into a vein, the active pharmaceutical ingredients subsequently spread throughout the body. This process is called distribution. Active ingredients distribute throughout the bloodstream, into tissues, and are eliminated through metabolism and excretion. Mathematically, the volume of … Volume of Distribution
Synonyms in a broader sense Leukemia, white blood cancer, Philadelphia chromosome Definition CML (chronic myeloid lekemia) shows a chronic, i.e. rather slowly progressing course of the disease. This leads to the degeneration of a stem cell, which is a precursor of granulocytes in particular, i.e. cells that are important for the defence against mainly bacteria. … Chronic myeloid leukaemia (CML)
Chronic phase Most often, chronic myeloid leukaemia is discovered during the chronic phase. It corresponds to the initial stage of the disease and can last up to ten years. It often proceeds without symptoms, so that the initial diagnosis is often made rather coincidentally, e.g. in the context of a routine blood test by the … Chronic phase | Chronic myeloid leukaemia (CML)
Prognosis/life expectancy/healing chances According to the current state of science, chronic myeloid leukaemia cannot be cured with medication. In cases of advanced disease or lack of response to therapy, a bone marrow transplantation, which is curative in principle (i.e. promising to cure) but risky, can be considered. Therefore, it is not so easy to make … Prognosis/life expectancy/healing chances | Chronic myeloid leukaemia (CML)
Symptoms The possible signs and symptoms of chronic myeloid leukemia include: Fatigue Feeling sick Bleeding tendency Susceptibility to infectious diseases Lack of appetite, digestive problems, weight loss. Fever Night sweats Enlargement of the spleen and liver, pain. Disorders of hematopoiesis, bone marrow changes Pale skin In the bone marrow and blood, a strong proliferation and … Chronic Myeloid Leukemia
Imatinib is a tyrosine kinase inhibitor used primarily to treat chronic myeloid leukemia. It achieves good results in the treatment of chronic myeloid leukemia while being well tolerated. Its use in other malignancies is also possible. What is imatinib? Imatinib (trade name Gleevec) is a drug in the tyrosine kinase inhibitor group used to treat … Imatinib: Effects, Uses & Risks
Products Imatinib is commercially available in the form of film-coated tablets (Gleevec, Gleevec GIST, generic). It has been approved in many countries since 2001. Generics came on the market in 2016. They were not approved for the treatment of gastrointestinal stromal tumors (GIST) because this indication was still protected by a patent. In 2017, imatinib … Imatinib
