Products Asunaprevir is not currently registered in many countries. It has been approved in Japan since 2014 (Sunvepra, Bristol-Myers Squibb) and is used in combination with daclatasvir (Daklinza) as an interferon and ribavirin-free treatment. Structure and properties Asunaprevir (C35H46ClN5O9S, Mr = 748.3 g/mol) Effects Asunaprevir has antiviral properties. The effects are due to selective and … Asunaprevir
Products Telbivudine is commercially available in the form of film-coated tablets (Sebivo). It has been approved in many countries since 2006. The solution has been off the market since 2012. Structure and properties Telbivudine (C10H14N2O5, Mr = 242.2 g/mol) is a thymidine analog and a prodrug that is biotransformed in cells to the active metabolite … Telbivudine
What drugs are used for hepatitis C? Until 2014, hepatitis C was treated mainly with interferon and drugs that inhibit the multiplication of the virus. In most cases, interferon-α was administered in combination with ribavirin. Since 2015, new drugs that directly attack the virus have been approved. NS5-A inhibitors (Ledipasvir, Daclatasvir, Ombitasvir), NS5-B inhibitors (Sofosbuvir, … Medicines for hepatitis C
Ribavirin Rivavirin is a drug used to treat certain viral infections, a so-called antiviral drug. In chronic hepatitis C, ribavirin is administered in combination with interferon-α to prevent the hepatitis C-induced form of liver inflammation from worsening and to prevent progressive functional impairment of the liver. The active ingredient ribavirin inhibits the multiplication of viruses … Ribavirin | Medicines for hepatitis C
Costs Agents that end in -buvir have been available in Germany since 2014, whereby one tablet costs around €488. This corresponds to therapy costs of 43. 500€ for a person over 12 weeks. A pack for a four-week therapy with the drug Simeprevir costs about 9. 360€. Therapy with new drugs that end on -asvir, … Costs | Medicines for hepatitis C
What is an interferon? Interferons are important messengers of the natural immune system and prevent the spread of viral infections. Genetically engineered interferons have played a critical role in the treatment of hepatitis C and multiple sclerosis for several years. Interferons are endogenous proteins that belong to the group of cytokines. They play an important … Interferon in MS and Hepatitis C
