Products Isosorbide dinitrate is commercially available in many countries in the form of tablets, sustained-release tablets, sustained-release capsules, as an infusion concentrate, and as a spray (Isoket). The drug first came on the market in the 1940s. Structure and properties Isosorbide dinitrate (C6H8N2O8, Mr = 236.14 g/mol) exists as a white, fine, crystalline and odorless … Isosorbide Dinitrate
Products Isosorbide mononitrate was commercially available in the form of divisible extended-release tablets (Corangin). It was approved in many countries in 1987 and was withdrawn from the market in 2014. Other nitrates can be used as substitutes, such as isosorbide dinitrate. Structure and properties Isosorbide mononitrate (C6H9NO6, Mr = 191.1 g/mol) is an organic nitrate. … Isosorbide Mononitrate
Products Mouth sprays are commercially available as drugs, medical devices, and dietary supplements. Listed below are some active ingredients that are administered with an oral spray: Local anesthetics: Lidocaine Disinfectant: chlorhexidine Herbal extracts: chamomile, sage, echinacea. Gel former: celluloses Anti-inflammatory: benzydamine Antibiotics: Tyrothricin Nitrates: isosorbide dinitrate Weaning agents: nicotine Cannabinoids: cannabidiol (CBD), cannabis extract. Mouth … Mouth Sprays
Definition Esters are organic compounds formed by the reaction of an alcohol or phenol and an acid such as a carboxylic acid. The condensation reaction releases a water molecule. The general formula of esters is: esters can also be formed with thiols (thioesters), with other organic acids, and with inorganic acids such as phosphoric acid … Ester
Symptoms Diffuse esophageal spasm manifests as seizure-like pain behind the breastbone (chest pain) and difficulty swallowing. The pain may radiate to the arms and jaw, similar to angina. Other possible symptoms include shortness of breath, cramping and burning. The duration of attacks varies, ranging from seconds to minutes. They are often triggered by food intake, … Diffuse Esophageal Spasm
Products Nitrates are commercially available in the form of chewable capsules, transdermal patches, infusion preparations, ointment, sustained-release tablets, sustained-release capsules, and sprays. As the first representative, nitroglycerin was already produced in the 19th century and used for the treatment of angina pectoris. Nitrates are thus among the oldest synthetic drugs. Structure and properties Organic nitrates … Organic Nitrates
Active ingredient Isosorbiddinitrate (ISDN) Mode of action Isosorbide dinitrate belongs to the group of nitrates from which nitric oxide (NO) can be released after absorption into the body. Nitric oxide leads to dilation of blood vessels (vasodilation), especially of the veins and larger coronary arteries. Nitrates thus lead to a reduction in the so-called preload, … Isoket®
Contraindications Isosorbide dinitrate must not be used in cases of known hypersensitivity to the active substance, acute circulatory failure, cardiogenic shock, systolic blood pressure < 90 mmHg (hypotension), hypertrophic obstructive cardiomyopathy (HOCM), and narrowing of the mitral valve or aortic valve (stenosis). Interactions A combination of ISDN and drugs to treat erectile dysfunction from the … Contraindications | Isoket®
Background Phenylalanine is an essential amino acid that is not produced by the human organism itself. Phenylalanine ingested with food is produced by the enzyme phenylalanine hydroxylase and its cofactor 6-tetrahydrobiopterin (6-BH4) metabolized to tyrosine. Phenylketonuria is an autosomal recessive disorder caused by insufficient activity of phenylalanine hydroxylase, resulting in elevated blood phenylalanine levels, i.e., … Sapropterin
