low blood pressure

Pholedrin

Products Pholedrin is no longer available as a drug in many countries. It was formerly contained in Ortho-Maren capsules, among other products. Structure and properties Pholedrine (C9H13NO, Mr = 151.2 g/mol) Effects Pholedrine (ATC C01CA30) has sympathomimetic properties. Indications Orthostatic hypotensive circulatory complaints and circulatory dysregulation.

Phosphodiesterase-5 Inhibitors

Products Phosphodiesterase-5 inhibitors are commercially available in the form of film-coated tablets and meltable tablets. Sildenafil (Viagra) was the first active ingredient from this group to be approved in the United States, the EU, and many countries in 1998. Generics are also available today. Sildenafil was originally to be developed by Pfizer for the treatment … Phosphodiesterase-5 Inhibitors

Silodosin

Products Silodosin has been approved in hard capsule form in the United States since 2008, in the EU since 2010, and in many countries since 2016 (Urorec). Generic versions are registered in some countries. Structure and properties Silodosin (C25H32F3N3O4, Mr = 495.5) exists as a white to yellowish powder that is sparingly soluble in water. … Silodosin

Pramipexole

Products Pramipexole is commercially available in tablet and sustained-release tablet form (Sifrol, Sifrol ER, generics). It has been approved in many countries since 1997; generics were released in 2010 and entered the market in January 2011. Sifrol ER sustained-release tablets were relaunched by the original manufacturer in 2010. Structure and properties Pramipexole (C10H17N3S, Mr = … Pramipexole

Imidapril

Products Imidapril is registered as a powder for oral solution (Prilium). It has been approved in many countries since 2004. Imidapril has also been used in humans, but no human medicines are currently registered in many countries (Tanatril). Structure and properties Imidapril (C20H27N3O6, Mr = 405.4 g/mol) is a prodrug and is biotransformed by ester … Imidapril

Toadstool

Products With the exception of alternative medicine therapeutics, no medicines containing preparations from fly agaric are commercially available. Toadstools have great cultural significance. They are considered an iconic example of a mushroom, are believed to bring good luck, are used for decorations (e.g., Christmas), and appear in literature and popular culture (e.g., Super Mario, the … Toadstool

SGLT2 Inhibitor

Products In 2012, dapagliflozin (Forxiga) was approved in the EU as the first agent in the new group of SGLT2 inhibitors. Several drugs are now on the market worldwide (see below). Structure and properties The SGLT2 inhibitors are derived from phlorizin, a -glucoside and natural substance first isolated from apple tree bark in 1835. Phlorizin … SGLT2 Inhibitor

Sacubitril

Products The fixed combination of the neprilysin inhibitor sacubitril with valsartan was approved in the United States, the EU, and many countries in 2015 in the form of film-coated tablets (Entresto). The combination is also referred to as LCZ696. Structure and properties Sacubitril (C24H29NO5, Mr = 411.5 g/mol) is an ester prodrug that is hydrolyzed … Sacubitril

Safinamide

Products Safinamide is commercially available in the form of film-coated tablets (Xadago). It was approved in many countries and in the EU in 2015 and in the US in 2017. Structure and properties Safinamide (C17H19FN2O2, Mr = 302.3 g/mol) is an α-aminoamide derivative. Effects Safinamide (ATC N04BD03) has indirect dopaminergic properties. It is a selective … Safinamide

Clenbuterol

Products Clenbuterol is not commercially available as a human drug in many countries, but exclusively as a veterinary drug for the treatment of respiratory diseases (e.g., Ventipulmin ad us vet). It is available only on medical prescription. In other countries, clenbuterol is on the market in tablet and drop form (Spiropent). Structure and properties Clenbuterol … Clenbuterol

Dizziness and circulation

Circulatory problems are widespread and are often accompanied by attacks of dizziness, nausea, sweating or blackening of the eyes and even sudden loss of consciousness. Triggers for circulatory problems can include abrupt changes in the weather, getting up too quickly from a lying position or standing for long periods in crowds, but also severe pain. … Dizziness and circulation