Products Carvedilol is commercially available in tablet form (Dilatrend, generic). It has been approved in many countries since 1995. Carvedilol is also combined with ivabradine fixed (Carivalan). Structure and properties Carvedilol (C24H26N2O4, Mr = 406.5 g/mol) is a racemate, with both enantiomers participating in the pharmacological effects. It exists as a white crystalline powder that … Carvedilol
Products Prazosin is commercially available in some countries in tablet form. It is no longer approved in many countries. Structure and properties Prazosin (C19H21N5O4, Mr = 383.4 g/mol) is a quinazoline derivative. It is present in drugs as prazosin hydrochloride, a white crystalline substance that is sparingly soluble in water. Effects Prazosin (ATC C02CA01) is … Prazosin
Products Phenoxybenzamine is commercially available in the form of capsules (Dibenzyran). The drug is not registered in many countries. Structure and properties Phenoxybenzamine (C18H22ClNO, Mr = 303.8 g/mol) is a haloalkylamine. Effects Phenoxybenzamine (ATC C04AX02) is an irreversible alpha blocker that inactivates alpha receptors by alkylation. It blocks norepinephrine actions, is vasodilatory, and lowers blood … Phenoxybenzamine
Products Phentolamine was commercially available as a solution for injection in many countries (Regitin, out of trade). Structure and properties Phentolamine (C17H19N3O, Mr = 281.4 g/mol) is present in drugs as phentolamine mesilate, a white, crystalline, slightly hygroscopic powder that is readily soluble in water. Effects Phentolamine (ATC C04AB01) is a competitive nonselective alpha1– and … Phentolamine
Products Silodosin has been approved in hard capsule form in the United States since 2008, in the EU since 2010, and in many countries since 2016 (Urorec). Generic versions are registered in some countries. Structure and properties Silodosin (C25H32F3N3O4, Mr = 495.5) exists as a white to yellowish powder that is sparingly soluble in water. … Silodosin
Products Bunazosin is commercially available in the form of sustained-release tablets (Andante). The drug is not registered in many countries. Structure and properties Bunazosin (C19H27N5O3, Mr = 373.4 g/mol) is present in drugs as bunazosin hydrochloride. It is a quinazoline derivative. Effects Bunazosin (ATC C02CA) is antihypertensive. Its effects are due to selective and competitive … Bunazosin
