Products Isosorbide dinitrate is commercially available in many countries in the form of tablets, sustained-release tablets, sustained-release capsules, as an infusion concentrate, and as a spray (Isoket). The drug first came on the market in the 1940s. Structure and properties Isosorbide dinitrate (C6H8N2O8, Mr = 236.14 g/mol) exists as a white, fine, crystalline and odorless … Isosorbide Dinitrate
Products Isosorbide mononitrate was commercially available in the form of divisible extended-release tablets (Corangin). It was approved in many countries in 1987 and was withdrawn from the market in 2014. Other nitrates can be used as substitutes, such as isosorbide dinitrate. Structure and properties Isosorbide mononitrate (C6H9NO6, Mr = 191.1 g/mol) is an organic nitrate. … Isosorbide Mononitrate
Products Medicinal products containing preparations of opium, such as the opium tincture or an opium extract, are used less frequently. In contrast, the pure alkaloids such as morphine and codeine and related opioids are very commonly used medicinally, especially in pain management. Opium and the opioids are subject to narcotics laws. Stem plant The opium … Opium Poppy
Products Nebivolol is commercially available in tablet form as a monopreparation (Nebilet, generic, USA: Bystolic) and in combination with hydrochlorothiazide (Nebilet plus). The active ingredient has been approved in many countries since 1998. A fixed combination with valsartan is also available in some countries (Byvalson). Structure and properties Nebivolol (C22H25F2NO4, Mr = 405.4 g/mol) has … Nebivolol
Products Clomethiazole is commercially available in capsule form and as a mixture (Distraneurin, UK: Heminevrin). It was developed at Roche in the 1930s. Structure and properties Clomethiazole (C6H8ClNS, Mr = 161.65 g/mol) is a chlorinated and methylated thiazole derivative. The compound is related to the thiazole moiety of vitamin B1 (thiamine). Effects Clomethiazole (ATC N05CM02) … Clomethiazole
Products Tricyclic antidepressants are commercially available in many countries in the form of dragées, tablets, capsules, and drops. The first representative, imipramine, was developed at Geigy in Basel. Its antidepressant properties were discovered in the 1950s by Roland Kuhn at the psychiatric clinic in Münsterlingen (Thurgau). Imipramine was approved in many countries in 1958. Structure … Tricyclic Antidepressants
Products Isoflurane is commercially available as a pure liquid and has been approved in many countries since 1984 (Forene, generic). Structure and properties Isoflurane (C3H2ClF5O, Mr = 184.5 g/mol) exists as a clear, colorless, mobile, heavy, stable, and nonflammable liquid that is practically insoluble in water. It has a slightly pungent and ether-like odor. The … Isoflurane
Products Amyl nitrite is commercially available in the form of ampoules (Amyle Nitrite Inhalant USP). The product, available in many countries, is imported from abroad and is not officially approved as a drug. Amyl nitrite is included in the Federal Office of Public Health‘s antidote list and must be stocked in hospitals for the treatment … Amyl Nitrite
Symptoms Anaphylaxis is a serious, life-threatening, and generalized hypersensitivity reaction. It usually occurs suddenly and affects various organs. It manifests itself in the following symptoms, among others: Respiratory symptoms: difficult breathing, bronchospasm, breathing sounds, coughing, undersupply of oxygen. Cardiovascular complaints: Low blood pressure, rapid heartbeat, chest pain, shock, collapse, unconsciousness. Skin and mucous membranes: Swelling, … Anaphylaxis
Products Methocarbamol is approved in tablet form (Metoflex). However, it is an older active ingredient, as it was first approved in the United States, for example, in the 1950s. Structure and properties Methocarbamol (C11H15NO5, Mr = 241.2 g/mol) is a carbamate derivative. It exists as a white powder and is sparingly soluble in water. Methocarbamol … Methocarbamol
Products Telmisartan is commercially available in tablet form (Micardis, Micardis Plus + hydrochlorothiazide, generics). It has been approved in many countries since 1998. Generics entered the market in December 2013. In 2010, a fixed combination with amlodipine was registered (Micardis Amlo). Kinzal is no longer marketed in many countries. Structure and properties Telmisartan (C33H30N4O2, Mr … Telmisartan
Products Gilteritinib was approved in the form of film-coated tablets in the United States in 2018, in the EU in 2019, and in many countries in 2020 (Xospata). Structure and properties Gilteritinib (C29H44N8O3, Mr = 552.7 g/mol) is present in the drug as gilteritinib fumarate, a light yellow to yellow powder or crystals that are … Gilteritinib