Products Rivaroxaban is commercially available in the form of film-coated tablets (Xarelto, Xarelto vascular). It was approved in 2008 as the first agent in the direct factor Xa inhibitor group. Low-dose Xarelto vascular, 2.5 mg, was registered in many countries in 2019. Structure and properties Rivaroxaban (C19H18ClN3O5S, Mr = 435.9 g/mol) is a pure -enantiomer … Rivaroxaban
Intestinal absorption After ingestion of a drug, the active ingredient must first be released. This process is called release (liberation), and it is a prerequisite for subsequent absorption. Absorption (formerly: resorption) is the passage of an active pharmaceutical ingredient from the digestive pulp into the bloodstream in the stomach and intestines. Absorption occurs primarily in … Absorption
Products Entacapone was commercially available in the form of film-coated tablets (Comtan). It was approved in many countries since 1999. In 2017, distribution was discontinued. A fixed combination with levodopa and carbidopa has also been available since 2004 (Stalevo). Generic versions of the combination drug were approved in 2014. Structure and properties Entacapone (C14H15N3O5, Mr … Entacapon
Definition Pharmaceutical agents are excreted primarily in the urine and, via the liver, in the bile in the stool. When excreted via the bile, they re-enter the small intestine, where they may be reabsorbed. They are transported back to the liver via the portal vein. This repetitive process is called the enterohepatic circulation. It prolongs … Enterohepatic Circulation
Products Benzhydrocodone was approved in the United States in 2018 as a fixed combination with acetaminophen in tablet form with a modified release of active ingredient (Apadaz). Structure and properties Benzhydrocodone (C25H25NO4, Mr = 403.5 g/mol) is an inactive prodrug of hydrocodone. It is an ester of benzoic acid with the opioid that is enzymatically … Benzhydrocodone
Products In many countries, human medicines with ammonium chloride as the active ingredient are no longer on the market. The salt is an ingredient in Mixtura solvens (Dissolving Mixture PH) and licorice. It used to be included in Bisolvon Linctus syrup along with bromhexine. In some countries, expectorants are available. Structure and properties Ammonium chloride … Ammonium Chloride
Products Obiltoxaximab was approved in the United States in 2016 as an infusion product (Anthim). It has not yet been registered in many countries. Obiltoxaximab was developed with funding from national organizations and is intended primarily for the treatment of victims of a terrorist attack with anthrax spores (Strategic National Stockpile). Structure and properties Obiltoxaximab … Obiltoxaximab
Products Many drugs are available in the form of suppositories. The most commonly administered in the office are acetaminophen suppositories for the treatment of fever and pain in infants and children (photo, click to enlarge). Definition Suppositories are single-dose medicinal preparations with a solid consistency. They usually have an elongated, torpedo-like shape and a smooth … Suppositories (Suppositories)
Products The first agent in the GLP-1 receptor agonist group to be approved was exenatide (Byetta) in the United States in 2005 and in many countries and the EU in 2006. In the meantime, several other drugs have been registered (see below). These drugs are also known as incretin mimetics. They are commercially available as … GLP-1 Receptor Agonists
Symptoms The possible acute symptoms of type 1 diabetes include: Thirst (polydipsia) and hunger (polyphagia). Increased urination (polyuria). Visual disturbances Weight loss Fatigue, exhaustion, declining performance. Poor wound healing, infectious diseases. Skin lesions, itching Acute complications: Hyperacidity (ketoacidosis), coma, hyperosmolar hyperglycemic syndrome. The disease usually manifests in childhood or adolescence and is therefore also called … Diabetes Mellitus Type 1
Pharmacodynamics and pharmacokinetics. When we take a tablet, we are usually interested in its immediate effects. The drug is supposed to relieve a headache or reduce symptoms of a cold. At the same time, we may think about the possible side effects it may trigger. The desired and undesired effects that a drug exerts on … ADME
Products Pethidine is commercially available as a solution for injection. It has been approved in many countries since 1947. The drug is subject to strict control as a narcotic and is available only by prescription. Structure and properties Pethidine (C15H21NO2, Mr = 247.3 g/mol) is a phenylpiperidine derivative. In pharmaceuticals, it is present as pethidine … Pethidine
