Products Dasatinib is commercially available in the form of film-coated tablets (Sprycel). It has been approved in many countries since 2007. Generic versions were registered in 2020. Structure and properties Dasatinib (C22H26ClN7O2S, Mr = 488.0 g/mol) exists as a white powder that is insoluble in water. It is an aminopyrimidine derivative. Effects Dasatinib (ATC L01XE06) … Dasatinib
Products Nilotinib is commercially available in capsule form (Tasigna). It has been approved in many countries since 2007. Structure and properties Nilotinib (C28H22F3N7O, Mr = 529.5 g/mol) is present in the drug product as nilotinib hydrochloride monohydrate, a white to slightly yellowish or greenish-yellow powder. The aminopyrimidine is structurally closely related to its precursor imatinib … Nilotinib
Products Bosutinib is commercially available in the form of film-coated tablets (Bosulif). The drug was approved in many countries in 2014. Structure and properties Bosutinib (C26H29Cl2N5O3, Mr = 530.4 g/mol) is a quinoline and piperazine derivative. It is present in drugs as bosutinib monohydrate, a white to yellowish powder that is sparingly soluble in water. … Bosutinib
Symptoms The possible signs and symptoms of chronic myeloid leukemia include: Fatigue Feeling sick Bleeding tendency Susceptibility to infectious diseases Lack of appetite, digestive problems, weight loss. Fever Night sweats Enlargement of the spleen and liver, pain. Disorders of hematopoiesis, bone marrow changes Pale skin In the bone marrow and blood, a strong proliferation and … Chronic Myeloid Leukemia
Products Imatinib is commercially available in the form of film-coated tablets (Gleevec, Gleevec GIST, generic). It has been approved in many countries since 2001. Generics came on the market in 2016. They were not approved for the treatment of gastrointestinal stromal tumors (GIST) because this indication was still protected by a patent. In 2017, imatinib … Imatinib
