Products Empagliflozin is commercially available in the form of film-coated tablets. It was approved in the EU, the United States, and many countries in 2014 (Jardiance). Empagliflozin is also combined fixed with metformin (Jardiance Met) as well as with linagliptin (Glyxambi). Trijardy XR is a fixed combination of empagliflozin, linagliptin, and metformin. Structure and properties … Empagliflozin
Products Dapagliflozin is commercially available in the form of film-coated tablets (Forxiga). It was approved in the EU in 2012 and in the United States and many countries in 2014. Dapagliflozin is also combined fixed with metformin (Xigduo XR). A fixed combination with saxagliptin was approved in 2017 (Qternmet film-coated tablets). Qternmet XR is a … Dapagliflozin
Products Canagliflozin is commercially available in the form of film-coated tablets (Invokana). It was approved in the United States and EU in 2013 and in many countries in 2014. Vokanamet is a fixed combination of canagliflozin and metformin. It was also registered in many countries in 2014. Structure and properties Canagliflozin (C24H25FO5S, Mr = 444.5 … Canagliflozin
Products No finished drug products containing phlorizin are commercially available in many countries. Phlorizin served as a precursor to modern SGLT2 inhibitors, which are antidiabetic drugs administered to treat type 2 diabetes. Structure and properties Phlorizin (C21H24O10, Mr = 436.4 g/mol) is a natural substance from apple tree bark. Effects Unlike modern SGLT2 inhibitors, phlorizin … Phlorizin
Products In 2012, dapagliflozin (Forxiga) was approved in the EU as the first agent in the new group of SGLT2 inhibitors. Several drugs are now on the market worldwide (see below). Structure and properties The SGLT2 inhibitors are derived from phlorizin, a -glucoside and natural substance first isolated from apple tree bark in 1835. Phlorizin … SGLT2 Inhibitor
