Products Dacomitinib was approved in the US in 2018 and in the EU and many countries in 2019 in film-coated tablet form (Vizimpro). Structure and properties Dacomitinib (C24H25ClFN5O2, Mr = 469.9 g/mol) is present in the drug product as dacomitinib monohydrate, a white to pale yellow powder. Effects Dacomitinib (ATC L01XE47) has antitumor and antiproliferative … Dacomitinib
Background Vitamin B12 can be produced exclusively by microorganisms and is found primarily in animal sources of protein, such as meat, liver, kidney, fish, oysters, milk, in dairy products and egg yolks. It plays an essential role in DNA synthesis, the formation of red blood cells and mucous membranes, and in myelination in the nervous … Vitamin B12 Deficiency Causes
Symptoms Diffuse esophageal spasm manifests as seizure-like pain behind the breastbone (chest pain) and difficulty swallowing. The pain may radiate to the arms and jaw, similar to angina. Other possible symptoms include shortness of breath, cramping and burning. The duration of attacks varies, ranging from seconds to minutes. They are often triggered by food intake, … Diffuse Esophageal Spasm
Products Esomeprazole is commercially available as tablets, film-coated tablets, granules for oral suspension, and injectables (Nexium, generics). It has been approved in many countries since 2000. Generics entered the market in 2012. Fixed combinations: Naproxen and esomeprazole (Vimovo, 2011). Acetylsalicylic acid and esomeprazole (Axanum, 2012), not commercially available. Structure and properties Esomeprazole (C17H19N3O3S, Mr = … Esomeprazole
Products Ulipristal acetate was approved in the EU in 2009 and in the United States in 2010 (ellaOne, film-coated tablets). In many countries, ulipristal acetate was registered in late 2012. Since February 1, 2016, the morning-after pill has been available in pharmacies without a doctor’s prescription after a consultation and dispensing documentation (see also under … Ulipristal Acetate
Products Proton pump inhibitors (PPIs) are commercially available in many countries in the form of film-coated tablets, MUPS tablets, capsules, as granules for preparation of an oral suspension, and as injectable and infusion preparations. The first active ingredient from this group to be approved in many countries was omeprazole (Antra, Losec), developed by Astra in … Proton Pump Inhibitors
Symptoms The leading symptoms of stomach burning include an uncomfortable burning sensation behind the breastbone and acid regurgitation. The burning sensation occurs primarily after eating, and pain along the esophagus may radiate. Other accompanying symptoms include hoarseness, coughing, nausea, difficulty swallowing, sleep disturbances, respiratory problems, a foreign body sensation in the throat, and enamel changes. … Stomach Burn
Products Several drugs are commercially available as enteric-coated tablets. Listed below are active ingredients that are administered with this dosage form: Proton pump inhibitors such as pantoprazole and esomeprazole. Some painkillers, e.g., NSAIDs such as diclofenac Digestive enzymes: pancreatin Laxative: bisacodyl Salicylates: mesalazine, acetylsalicylic acid 100 mg. Structure and properties Enteric coated tablets belong to … Enteric-Coated Tablets
Products Rabeprazole is commercially available in the form of film-coated tablets (Pariet, generic). It has been approved in many countries since 1999. Generic versions have been available since 2012. Structure and properties Rabeprazole (C18H21N3O3S, Mr = 359.4 g/mol) is a benzimidazole and pyridine derivative and a racemate. It is present in drugs as rabeprazole sodium, … Rabeprazole
Definition The term “reflux esophagitis” describes an inflammation of the lower esophagus caused by contact of the esophageal mucosa with gastric acid. The causes, stages, courses and consequences of this disease can be numerous. Overall, these complaints are a very widespread problem, since up to 20% of the western population suffer from acid-related mucous membrane … Reflux esophagitis
Treatment The treatment depends on the severity and duration of the complaints, as well as the patient’s circumstances. The first priority is to change eating and living habits in order to cure or prevent initial symptoms such as heartburn or mild reflux esophagitis. The change must include the avoidance of risk factors, i.e. a low-fat … Treatment | Reflux esophagitis
Associated symptoms The main symptoms of reflux esophagitis are heartburn, pain behind the sternum, as well as a feeling of pressure and pain when swallowing. The symptoms depend on the time of day and physical activity. When lying down, these pains are often worsened because the acid can rise even more easily into the esophagus. … Associated symptoms | Reflux esophagitis
