Prolongation of the QT Interval

Symptoms Drug-induced prolongation of the QT interval can rarely lead to severe arrhythmias. This is polymorphic ventricular tachycardia, known as torsade de pointes arrhythmia. It can be seen on the ECG as a wave-like structure. Due to the dysfunction, the heart cannot maintain blood pressure and can only pump insufficient blood and oxygen to the … Prolongation of the QT Interval

Mefloquine: Effects, Uses & Risks

Mefloquine is the name of an active ingredient used to treat and prevent malaria. Due to its severe side effects, the manufacturer has stopped selling the drug in Germany. What is mefloquine? Mefloquine was jointly developed by Swiss pharmaceutical company F. Hoffmann-La-Roche AG and a U.S. Army institute to treat the tropical disease malaria. Prevention … Mefloquine: Effects, Uses & Risks

Quinine

Products Quinine is approved in many countries in the form of dragées for malaria therapy (quinine sulfate 250 Hänseler). In Germany, film-coated tablets of 200 mg quinine sulfate are commercially available for the treatment of calf cramps (Limptar N). Structure and properties Quinine (C20H24N2O2, Mr = 324.4 g/mol) usually exists as quinine sulfate, a white … Quinine

Chinese Tree

Stem plant Vahl, Rubiaceae, China tree. Medicinal drug Cinchonae cortex – cinchona bark: the whole or cut bark of Vahl ( Pavon), of (Weddell), of (Moens ex Trimen), of their varieties and hybrids (PhEur). The PhEur requires a minimum content of alkaloids. Preparations Cinchonae extractum ethanolicum liquidum Ingredients Alkaloids: quinine, quinidine, cinchonine, cinchonidine. Tannins Effects … Chinese Tree

Mefloquine

Products Mefloquine is commercially available in the form of film-coated tablets (generic: mephaquine). The active ingredient was approved in many countries in 1984. Distribution of the original Lariam (Roche) was discontinued in 2014 for commercial reasons. Structure and properties Mefloquine (C17H16F6N2O, Mr = 378.3 g/mol) is a fluorinated quinoline and piperidine derivative and an analog … Mefloquine

Pharmaceutical Active Ingredient

Definition Active ingredients are the active components of a drug that are responsible for its pharmacological effects. Drugs may contain a single active ingredient, multiple active ingredients, or complex mixtures such as herbal extracts. In addition to the active ingredients, a drug contains various excipients that should be as pharmacologically inert as possible. The percentage … Pharmaceutical Active Ingredient

Alkaloids

Products Alkaloids and their derivatives are contained as active ingredients in numerous medicines. They have been used medicinally for thousands of years, such as opium with morphine or coca leaves with cocaine. In 1805, a pure alkaloid was extracted for the first time by the German pharmacist Friedrich Sertürner with morphine. Structure and properties Alkaloids … Alkaloids

Babesiosis in Dogs

Symptoms The disease manifests itself differently depending on the pathogen, age and condition of the animal can also be subclinical. Possible symptoms include high fever, lassitude, poor appetite, weight loss, hemolytic anemia (anemia), pale mucous membranes, hemoglobinuria, brown urine, and jaundice. In addition, oedema, bleeding, splenomegaly, thrombocytopenia, ocular disease, and complications of various organs may … Babesiosis in Dogs

Chloroquine

Products Chloroquine was commercially available in tablet form (Nivaquine). It was approved in many countries since 1953. Its distribution was discontinued in 2019. It was first synthesized in 1934 by Hans Andersag at Bayer in Elberfeld (I.G. Farbenindustrie). Currently, medicines containing chloroquine are no longer available in many countries. Magisterial formulations can be made in … Chloroquine