CYP450 Cytochromes P450s are a family of enzymes that are of paramount importance in drug biotransformation. The most important isoenzymes for drug metabolism are: CYP1A1, CYP1A2 CYP2B6 CYP2C9, CYP2C19 CYP2D6 CYP2E1 CYP3A4, CYP3A5 and CYP3A7 The number after the abbreviation CYP stands for the family, the following letter for the subfamily and the last number … Cytochrome P450 (CYP)
Products Isavuconazonium sulfate is commercially available as a powder for a concentrate for the preparation of an infusion solution and in capsule form (Cresemba). It was approved in the US and EU in 2015 and in many countries in 2017. Structure and properties Isavuconazonium sulfate (C35H35F2N8O5S+ – HSO4– Mr = 814.8 g/mol) is a prodrug … Isavuconazonium Sulfate
Products Antibiotics (singular: antibiotic) are commercially available in the form of tablets, dispersible tablets, capsules, as infusion preparations, suspensions and syrups for children, and as granules, among others. There are also some topical preparations, such as creams, ointments, eye drops, eye ointments, ear drops, nasal ointments and sore throat tablets. The first active ingredient from … Antibiotics: Antibacterial Drugs
Definition Glucuronidation refers to an intracellular metabolic reaction in which an endogenous or exogenous substrate is conjugated to glucuronic acid. The organism thereby makes the substrates more water soluble so that they can be rapidly excreted in the urine. Glucuronidation belongs to phase II metabolism (conjugations). UDP: uridine diphosphate UGT: UDP-glucuronosyltransferase Enzymes involved Glucuronidation is … Glucuronidation
Products Rifabutin is commercially available in capsule form (mycobutin). It has been approved in many countries since 1994. Structure and properties Rifabutin (C46H62N4O11, Mr = 847 g/mol ) is a semisynthetic ansamycin antibiotic. It exists as a reddish purple amorphous powder that is sparingly soluble in water. Effects Rifabutin (ATC J04AB04) has antibacterial properties against … Rifabutin
Products Rifampicin is commercially available as film-coated tablets, coated tablets, capsules, and injectables (Rimactan, generics). In addition to mono, various combination preparations are also available. Rifampicin has been approved in many countries since 1968. This article refers to peroral monotherapy. Structure and properties Rifampicin (C43H58N4O12, Mr = 823 g/mol) exists as a reddish brown to … Rifampicin
Products Rifamycin is commercially available in the form of ear drops (Otofa). It has been approved in many countries since 1988. Structure and properties Rifamycin (Rifamycin SV) is present in the drug as rifamycin sodium, a fine or slightly granular red powder that is soluble in water (C37H46NNaO12, Mr = 720 g/mol). It is obtained … Rifamycin
Products Rifaximin is commercially available in the form of film-coated tablets (Xifaxan). It was approved in many countries in 2015. In many countries, it was available earlier. Rifaximin was first released in Italy in the 1980s. Structure and properties Rifaximin (C43H51N3O11, Mr = 785.9 g/mol) is a semisynthetic pyridoimidazole derivative of rifamycin. It exists as … Rifaximin
