Products Hydrochlorothiazide is commercially available in numerous antihypertensive agents in combination with ACE inhibitors, sartans, renin inhibitors, potassium-sparing diuretics, calcium channel blockers, and beta blockers. Use as a monopreparation (Esidrex) is less common. Hydrochlorothiazide has been approved in many countries since 1958. Structure and properties Hydrochlorothiazide (C7H8ClN3O4S2, Mr = 297.7 g/mol) is a white crystalline … Hydrochlorothiazide
Products Telmisartan is commercially available in tablet form (Micardis, Micardis Plus + hydrochlorothiazide, generics). It has been approved in many countries since 1998. Generics entered the market in December 2013. In 2010, a fixed combination with amlodipine was registered (Micardis Amlo). Kinzal is no longer marketed in many countries. Structure and properties Telmisartan (C33H30N4O2, Mr … Telmisartan
Products Drospirenone is commercially available as a fixed combination with ethinyl estradiol for contraception in the form of film-coated tablets (Yasmin, Yasminelle, YAZ, generics, auto-generics). Drospirenone is also used in combination with estradiol for hormone replacement therapy (Angeliq). Bayer’s originals Yasmin, Yasminelle and YAZ will go off the market in many countries in December 2021. … Drospirenone
Products Eprosartan is commercially available in the form of film-coated tablets (Teveten, generics). It has been approved in many countries since 1999 and is also used in fixed combination with hydrochlorothiazide (Teveten plus, generic). Structure and properties Eprosartan (C23H24N2O4S, Mr = 424.5 g/mol) is present in drugs as eprosartan mesilate, a white crystalline powder that … Eprosartan
Products Candesartan is commercially available in tablet form (Atacand, Blopress, generics). It is also combined fixed with hydrochlorothiazide (Atacand plus, Blopress plus, generics). Candesartan has been approved in many countries since 1997. In 2020, a fixed combination with amlodipine was also released. Structure and Properties Candesartan (C24H20N6O3, Mr = 440.45 g/mol) is administered in the … Candesartan
Products Losartan is commercially available in the form of film-coated tablets (Cosaar, generics). It has been approved in many countries since 1994 and was the first agent in the sartan group. Losartan is also combined with the diuretic hydrochlorothiazide (Cosaar Plus, generic). Structure and properties Losartan (C22H23ClN6O, Mr = 422.9 g/mol) is a biphenyl, imidazole, … Losartan
Products Irbesartan is commercially available in the form of film-coated tablets as a monopreparation (Aprovel, generic) and as a fixed combination with hydrochlorothiazide (Co-Aprovel). It has been approved in many countries since 1997. Generics entered the market in many countries in August 2012. Generic versions of the combination preprinted with hydrochlorothiazide went on sale in … Irbesartan
Symptoms A heart attack manifests itself in acute and severe pain and a feeling of tightness and pressure in the chest, which may also radiate to the arms, jaw or abdomen. Other symptoms include nausea, indigestion, shortness of breath, coughing, a break of sweat, pallor, fear of death, unconsciousness and dizziness. A myocardial infarction lasts … Heart Attack Causes and Treatment
Products Benazepril was commercially available as film-coated tablets (Cibacen, off label). It was also available as a fixed-dose combination with hydrochlorothiazide (Cibadrex, off label). Benazepril was approved in many countries beginning in 1990. Structure and properties Benazepril (C24H28N2O5, Mr = 424.5 g/mol) is present in drugs as benazepril hydrochloride, a white crystalline powder that is … Benazepril
Products Aliskiren is commercially available in the form of film-coated tablets (Rasilez, Rasilez HCT + hydrochlorothiazide). It was approved in many countries, in the EU and in the United States in 2007 (Other brand name: Tekturna). Note: Other combination preparations, e.g., with amlodpine (Rasilamlo), are no longer available. Structure and properties Aliskiren (C30H53N3O6, Mr = … Aliskiren
Products Ramipril is commercially available in tablet and capsule form (Triatec, generics). It has been approved in many countries since 1994 and is also available as a fixed combination with other agents. Structure and properties Ramipril (C23H32N2O5, Mr = 416.5 g/mol) exists as a white crystalline powder that is sparingly soluble in water. It is … Ramipril: Drug Effects, Side Effects, Dosage and Uses
Background Potassium ions play an important role in many biological processes, particularly in the generation of membrane and action potentials and electrical conduction in nerve cells and the heart. Potassium is 98% localized intracellularly. The primary active transporter Na+/K+-ATPase provides transport into cells. Two hormones maintain the deep extracellular potassium concentration. The first is insulin, … Hyperkalemia (High Potassium)
