Products
Ramipril is commercially available in tablet and capsule form (Triatec, generics). It has been approved in many countries since 1994 and is also available as a fixed combination with other agents.
Structure and properties
Ramipril (C23H32N2O5, Mr = 416.5 g/mol) exists as a white crystalline powder that is sparingly soluble in water. It is a prodrug and is hydrolyzed in the body to the active ingredient ramiprilat.
Effects
Ramipril (ATC C09AA05) has antihypertensive properties and unloads the heart (preload and afterload). The effects are due to inhibition of the formation of angiotensin II from angiotensin I by inhibition of angiotensin converting enzyme (ACE). Ramipril thus abolishes the effects of antiogensin II.
Indications
- Hypertension
- Heart failure
- Long-term prophylaxis after myocardial infarction in patients with heart failure.
- For the prevention of cardiovascular disease at increased risk or diabetes mellitus type 2.
- Glomerular nephropathy with proteinuria
Dosage
According to the professional information. The tablets can be taken independently of meals.
Contraindications
- Hypersensitivity
- Previous angioedema while taking ACE inhibitors or sartans.
- Hereditary or idiopathic angioedema
- Renal artery stenosis
- Severe renal dysfunction
- Pregnancy
- Concurrent use of aliskiren in patients with diabetes mellitus or impaired renal function.
Full details of precautions and interactions can be found in the drug label.
Adverse effects
The most common possible adverse effects include a rash, chest pain, fatigue, headache, mild drowsiness, irritable cough, muscle cramps or pain, low blood pressure, and digestive problems.
