Products The fixed combination of netupitant and palonosetron has been approved in capsule form (Akynzeo). The drug was released in many countries in 2015. Structure and properties Netupitant (C30H32F6N4O, Mr = 578.6 g/mol) is a fluorinated piperazine and pyrimidine derivative. Palonosetron (C19H24N2O, Mr = 296.4 g/mol) is present in drugs as palonosetron hydrochloride, a white … Netupitant, Palonosetron
Products Ondansetron is commercially available in the form of film-coated tablets, meltable tablets (lingual tablets), as a syrup, and as an infusion/injection preparation. In addition to the original Zofran, generic versions are also available. Ondansetron was introduced in 1991 as the first active ingredient from the group of 5-HT3 receptor antagonists was approved. Structure and … Ondansetron
Products Ketanserin is commercially available as a gel (Vulketan). It has been approved in many countries since 1995 and exclusively as a veterinary drug. In other countries, it is also available for human use as an antihypertensive. Structure and properties Ketanserin (C22H22FN3O3, Mr = 395.4 g/mol) is a quinazolinone derivative. Ketanserin hydrogenotartrate is used in … Ketanserin
Products Metergoline is commercially available in the form of tablets for animals. It has been approved in many countries since 1990. Structure and properties Metergoline (C25H29N3O2, Mr = 403.5 g/mol) is a synthetic ergoline derivative. Effects Metergoline (ATCvet QG02CB05) has antiserotoninergic properties and inhibits prolactin secretion. The effects are due to antagonism at serotonin 5HT … Metergolin
Products Antiemetics are commercially available in the form of tablets, as melting tablets, as solutions (drops), and injectables, among others. They are also administered as suppositories because peroral administration is not possible. In many countries, the best-known antiemetics include domperidone (Motilium, generic) and meclozine, which, along with caffeine and pyridoxine, is contained in Itinerol B6. … Antiemetics: Drugs against Nausea or Vomiting
Products Granisetron is commercially available as film-coated tablets and as an infusion concentrate (Kytril, generic). It has been approved in many countries since 1991. A transdermal patch was approved in the EU in 2012 (Sancuso). Structure and properties Granisetron (C18H24N4O, Mr = 312.4 g/mol) is an indazole derivative. It is present in drugs as granisetron … Granisetron
Symptoms The preliminary stages are fatigue, yawning, difficulty concentrating, headache, mood swings, lethargy, and an increased need for sleep. The actual motion sickness manifests itself acutely in symptoms such as cold sweat, pallor, pale complexion, sensations of warmth and cold, faintness, hyperventilation, rapid pulse rate, low blood pressure, salivation, nausea, nausea, vomiting, and dizziness. Triggers … Motion Sickness
Products Dolasetron (Anzemet) is no longer on the market in many countries. It had been approved since 1999. The solution for injection was withdrawn in 2011 because of possible adverse effects (prolongation of the QT interval, cardiac arrhythmias), and later the tablets also went off the market. Structure and properties Dolasetron (C19H20N2O3, Mr = 324.4 … Dolasetron
Symptoms Complaints include nausea and/or vomiting, which in a minority occur only in the morning, and in the majority also during the day. Because of throat irritation, additional throat clearing and coughing are often observed and, in a severe course, tightening of the rib muscles. Course For most pregnant women, normal, self-limiting symptoms with no … Pregnancy Vomiting
Products Palonosetron is commercially available as a solution for injection and as soft capsules (Aloxi, generic). It has been approved in many countries since 2006. The capsules were registered in 2013. Also approved is a fixed combination of netupitant and palonosetron in capsule form; see netupitant palonosetron. Structure and properties Palonosetron (C19H24N2O, Mr = 296.4 … Palonosetron
Background Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter biosynthesized from the amino acid tryptophan by decarboxylation and hydroxylation. It binds to seven different families of the serotonin receptor (5-HT1 to 5-HT7) and elicits central and peripheral effects that affect mood, behavior, sleep-wake cycle, thermoregulation, pain perception, appetite, vomiting, muscles, and nerves, among others. Serotonin is vasoconstrictive … Serotonin Syndrome: Causes and Treatment
Products Tropisetron was approved in many countries starting in 1992 as a solution for injection and in capsule form (Navoban). It was withdrawn from the market in 2013. Structure and properties Tropisetron (C17H20N2O2, Mr = 284.4 g/mol) is an indole and tropane derivative. It exists as a white powder that is soluble in water. Effects … Tropisetron
