Products Sildenafil is commercially available in the form of film-coated tablets and as a solution for injection (Viagra, Revatio, generics). It has been approved in many countries since 1998. Generics went on sale July 22, 2013, and the patent expired June 21. Pfizer launched auto-generic sildenafil Pfizer, identical to the original, back in May. In … Sildenafil
Definition When two or more drugs are combined, they may affect each other. This is especially true with regard to their pharmacokinetics (ADME) and effects and adverse effects (pharmacodynamics). This phenomenon is called interaction and drug-drug interaction. Interactions are usually undesirable because they can lead to, for example, loss of efficacy, side effects, poisoning, hospitalization, … Interactions
Products Amyl nitrite is commercially available in the form of ampoules (Amyle Nitrite Inhalant USP). The product, available in many countries, is imported from abroad and is not officially approved as a drug. Amyl nitrite is included in the Federal Office of Public Health‘s antidote list and must be stocked in hospitals for the treatment … Amyl Nitrite
Background That grapefruit juice can cause drug-drug interactions was discovered by chance in a clinical trial in 1989 and confirmed in an experiment by the same research group in 1991 (Bailey et al, 1989, 1991). This showed that simultaneous ingestion of grapefruit juice with the calcium channel blocker felodipine significantly increases the bioavailability of felodipine. … Interactions with Grapefruit Juice
Products Nicorandil is commercially available in tablet form (Dancor). It has been approved in many countries since 1993. Structure and properties Nicorandil (C8H9N3O4, Mr = 211.2 g/mol), like nitroglycerin, is an organic nitrate. It is a combination of the vitamin nicotinamide with an ethyl nitrate. Effects Nicorandil (ATC C01DX16) has vasodilator, antihypertensive, and cardioprotective properties. … Nicorandil
Symptoms Diffuse esophageal spasm manifests as seizure-like pain behind the breastbone (chest pain) and difficulty swallowing. The pain may radiate to the arms and jaw, similar to angina. Other possible symptoms include shortness of breath, cramping and burning. The duration of attacks varies, ranging from seconds to minutes. They are often triggered by food intake, … Diffuse Esophageal Spasm
Products Nitrates are commercially available in the form of chewable capsules, transdermal patches, infusion preparations, ointment, sustained-release tablets, sustained-release capsules, and sprays. As the first representative, nitroglycerin was already produced in the 19th century and used for the treatment of angina pectoris. Nitrates are thus among the oldest synthetic drugs. Structure and properties Organic nitrates … Organic Nitrates
Products Uprima sublingual tablets (2 mg, 3 mg) for erectile dysfunction are no longer marketed in many countries. The marketing authorization was not renewed by Abbott AG in 2006. Commercial reasons were cited, probably attributed to competition from phosphodiesterase-5 inhibitors (e.g., sildenafil, Viagra). It is also possible that a post-marketing study had played a role, … Apomorphine
Products Alprostadil cream Vitaros was approved in many countries in 2016. It is an export approval. In some countries, it is marketed as Virirec. Structure and properties Alprostadil (C20H34O5, Mr = 354.5 g/mol) exists as a white to slightly yellowish crystalline powder that is practically insoluble in water. The substance structurally corresponds to natural prostaglandin … Alprostadil Cream
Products Nitroglycerin is commercially available in many countries in the form of chewable capsules (Nitroglycerin Streuli). The active ingredient was produced and used medicinally as early as the 19th century. Structure and properties Nitroglycerin or glycerol trinitrate (GTN, C3H5N3O9, Mr = 227.1 g/mol) is an organic nitrate. It is nitrated glycerol. Nitroglycerin exists as an … Nitroglycerin Capsules
Products Nitroglycerin has been approved in many countries since 1981 in the form of a transdermal patch (Nitroderm, others). Structure and properties Nitroglycerin or glycerol trinitrate (C3H5N3O9, Mr = 227.1 g/mol) is an organic nitrate. It is nitrated glycerol. Nitroglycerin exists as an oily liquid and is explosive if not stabilized. Synthesis Effects Nitroglycerin (ATC … Nitroglycerin Patch
Products Rectogesic ointment is approved in many countries (some countries: Rectiv). Nitroglycerin ointments are also used in a higher concentration for transdermal treatment of angina (2%). This article refers to rectal administration for anal fissure. Structure and properties Nitroglycerin or glycerol trinitrate (C3H5N3O9, Mr = 227.1 g/mol) is nitrated glycerol. Pure nitroglycerin is explosive and … Nitroglycerin Ointment
