smoothened receptor antagonists

Sonidegib

Products Sonidegib was approved in many countries in 2015 in capsule form (Odomzo). Structure and properties Sonidegib (C26H26F3N3O3, Mr = 485.5 g/mol) is present in the drug as sonidegib diphosphate. It is a biphenyl carboxamide. Effects Sonidegib (ATC L01XX48) has antitumor and antiproliferative properties. The effects are due to inhibition of the Hedgehog signaling pathway … Sonidegib

Vismodegib

Products Vismodegib is commercially available in capsule form (Erivedge). The drug was newly approved in many countries in May 2013. Structure and properties Vismodegib (C19H14Cl2N2O3S, Mr = 421.3 g/mol) is a chlorinated methylsulfonylbenzamide derivative and exists as a white to brownish powder. Effects Vismodegib (ATC L01XX43) has antitumor properties. The effects are due to inhibition … Vismodegib