Products Pasireotide is commercially available as an injectable (Signifor, Signifor LAR). It was approved in the EU and many countries in 2012. Structure and properties Pasireotide (C59H67N9O9, Mr = 1046.2 g/mol) is present in the drug as pasireotide diaspartate or as pasireotide pamoate. It is a cyclohexapeptide and an analog of the hormone somatostatin. Somatostatin … Pasireotide
Products Octreotide is commercially available as an injectable (Sandostatin, Sandostatin LAR, generics). It has been approved in many countries since 1988. Structure and properties Octreotide is a synthetic octapeptide derivative of the hormone somatostatin. It is present in the drug as octreotide acetate and has the following structure: D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-ol, xCH3COOH (x = 1.4 to 2.5). … Octreotide
Products Telotristat was approved in the United States in 2017 and in many countries in 2018 in film-coated tablet form (Xermelo). Structure and properties Telotristat (C27H26ClF3N6O3, Mr = 574.9 g/mol) is present in the drug as a salt of hippuric acid and as an ethyl ester prodrug. After absorption, the prodrug is rapidly hydrolyzed by … Telotristat
Products Lanreotide is commercially available as a solution for injection (Somatuline Autogel). It has been approved in many countries since 2004. Structure and properties Lanreotide is present in the drug as lanreotide acetate. It is a synthetic octapeptide analog of somatostatin with the following structure: D-βNal-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2, x(CH3COOH), where x = 1 to 2 Effects Lanreotide … Lanreotide
