How sumatriptan works Triptans such as sumatriptan enter the brain via the blood and activate certain docking sites (receptors) for the nerve messenger serotonin (5-HT1 receptor) on the surface of nerve cells and blood vessels in the brain. This causes the blood vessels, which are dilated during an attack, to constrict and also results in … Sumatriptan: Effects, Uses, Side Effects
Products Zolmitriptan is commercially available as film-coated tablets, meltable tablets, and as a nasal spray (Zomig, generics). It has been approved in many countries since 1997. Generic versions entered the market in 2012. Structure and properties Zolmitriptan (C16H21N3O2, Mr = 287.4 g/mol) is an indole and oxazolidinone derivative structurally related to serotonin. It exists as … Zolmitriptan
Products Sumatriptan is commercially available as film-coated tablets, nasal spray, injectable solution, and suppositories (Imigran, generics). It has been approved in many countries since 1993. Structure and properties Sumatriptan (C14H21N3O2S, Mr = 295.4 g/mol) is present in drugs as sumatriptan or in the form of the salt sumatriptan succinate. Sumatriptan succinate is a white powder … Sumatriptan
Products Nasal sprays are very widely used and there are many different products on the market, which are approved drugs or medical devices (see below). Nasal sprays are also manufactured in pharmacies. Structure and properties Nasal sprays are solutions, emulsions, or suspensions intended for spraying into the nasal cavities. They may contain one or more … Nasal Sprays
Products Triptans are mainly taken in the form of film-coated tablets and melting tablets. Some are also available as subcutaneous injectable solutions and nasal sprays. Suppositories are no longer commercially available in many countries. Sumatriptan (Imigran) was the first agent in this group to be approved in the United States in 1992 and in many … Triptans: Drug Effects, Side Effects, Dosage and Uses
Definition and properties The administration or application of a drug refers to its use on the body. The dosage forms (drug forms) used for this purpose consist of the active ingredients and excipients. These include, for example, tablets, capsules, solutions, syrups, injectables, creams, ointments, eye drops, ear drops, and suppositories. Drugs can be liquid, semi-solid, … Administration
Definition Medication overuse involves using self-purchased or physician-prescribed medications for too long, too much, or too frequently. The duration of therapy prescribed by a healthcare professional or by the professional and patient information is exceeded, the maximum single or daily dose is too high because of a dose increase, or the dosing interval is too … Medication Overuse
Symptoms Migraine occurs in attacks. It may announce itself up to three days before an attack with various precursors (prodromes). These include, for example: Mood changes Fatigue Hunger Frequent yawning Irritability Aura may occur before the headache phase in up to about one-third of patients: Visual disturbances such as flickering lights, dots or lines, facial … Migraine Headache
Background Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter biosynthesized from the amino acid tryptophan by decarboxylation and hydroxylation. It binds to seven different families of the serotonin receptor (5-HT1 to 5-HT7) and elicits central and peripheral effects that affect mood, behavior, sleep-wake cycle, thermoregulation, pain perception, appetite, vomiting, muscles, and nerves, among others. Serotonin is vasoconstrictive … Serotonin Syndrome: Causes and Treatment
The active ingredient sumatriptan is contained in medications used to treat acute migraine attacks or cluster headaches. On the one hand, the drug constricts the blood vessels during a migraine; on the other hand, it inhibits pain transmission. What is sumatriptan? The active ingredient sumatriptan is found in medications used to treat acute migraine attacks … Sumatriptan: Effects, Uses & Risks
Side effects of triptans Triptans are generally well tolerated. As with all drugs, triptans have side effects that need to be considered and weighed against the benefit of the drug. Weakness and/or dizziness are often reported after prolonged use of a triptan. The dizziness may sometimes be described as fluctuating or even spinning, sometimes a … Side effects of triptans | Triptans
Triptans during pregnancy Migraine occurs above all also with young women and therefore also more frequently in the pregnancy. In the first three months of pregnancy there are some well evaluated studies on triptan application. Here no abnormalities and no increased malformation or abortion rate were found during pregnancy. Although there are comparatively few studies … Triptans during pregnancy | Triptans
