Products Sunitinib is commercially available in capsule form (Sutent). It has been approved in many countries since 2006. Structure and properties Sunitinib (C22H27FN4O2, Mr = 398.5 g/mol) is present in the drug as sunitinibmalate, a yellow to orange powder that is soluble in water. It is an indolin-2-one and pyrrole derivative. It has an active … Sunitinib
Products Pazopanib is commercially available in the form of film-coated tablets (Votrient). It was approved in the EU and many countries in 2010. Structure and properties Pazopanib (C21H23N7O2S, Mr = 437.52 g/mol) exists in drugs as pazopanib hydrochloride, a white to yellowish solid that is sparingly soluble in water at pH 1 and practically insoluble … Pazopanib
Background Kinases (phosphotransferases) are a large family of enzymes involved in the transduction and amplification of signals on and in cells. They exert their effects by phosphorylating their substrates, that is, by adding a phosphate group to the molecules (Figure). Kinases have complicated names that are usually abbreviated: ALK, AXL, BCR-ABL, c-Kit, c-Met, ERBB, EGFR, … Kinase Inhibitors
Products Toceranib is commercially available in the form of film-coated tablets (Palladia). It is approved exclusively as a veterinary drug in many countries and has been since 2010. Structure and properties Toceranib (C22H25FN4O2, Mr = 396.5 g/mol) is present in drugs as the phosphate salt toceranib phosphate, a crystalline, yellow-orange powder. It has structural and … Toceranib
Sunitinib is an anticancer drug and is used for gastrointestinal stromal tumors (GIST) that can no longer be surgically removed, neuroendocrine tumors of the pancreas, or renal cell tumors. It is marketed under the trade name Sutent and is manufactured by Pfizer. Sunitinib can cause various side effects by interacting with thyroid hormones. What is … Sunitinib: Effects, Uses & Risks
Price Tyrosine kinase inhibitors are active ingredients from the group of genetically engineered monoclonal antibodies. This newer, targeted treatment of cancer is still very expensive. As a rule, it is a long-term or even life-long therapy to suppress a relapse. Glivec (contains the active ingredient Imatinib) in the therapy of chronic myeloid leukemia costs over … Price | Targeted cancer therapy with tyrosine kinase inhibitors
Synonyms Tyrosine kinase inhibitors include : imatinib, sunitinib, midostaurine and many others Introduction Tyrosine kinase inhibitors are also known as tyrosine kinase inhibitors. This is a group of drugs that inhibit the enzyme tyrosine kinase, which is involved in the development, survival and spread of cancer in the body. Tyrosine kinase inhibitors, such as the … Targeted cancer therapy with tyrosine kinase inhibitors
Side effects Tyroin kinase inhibitors are highly potent drugs. Their use can lead to side effects that do not necessarily occur in every patient. In some cases, these can be serious to life-threatening, which is why a doctor should be consulted immediately. In general, treatment with tyrosine kinase inhibitors requires close monitoring of symptoms and … Side effects | Targeted cancer therapy with tyrosine kinase inhibitors
Interaction Tyrosine kinase inhibitors, like many other drugs, are metabolised and broken down by certain enzymes in the liver. Thus, many drugs can influence the effect of tyrosine kinase inhibitors, but tyrosine kinase inhibitors can also influence other drugs. The effect can be enhanced, which is associated with an increased risk of side effects; or … Interaction | Targeted cancer therapy with tyrosine kinase inhibitors
