How ticagrelor works The anticoagulant ticagrelor specifically inhibits a certain binding site on the surface of blood platelets (thrombocytes), the so-called P2Y12 receptor for ADP. This suppresses the activation of further platelets and also further “self-activation” of platelets. The combination of ticagrelor with acetylsalicylic acid (ASA) in dual platelet inhibition additionally prevents the formation of … Ticagrelor: Effects, uses, side effects
Effects Antithrombotic Anticoagulant Fibrinolytic Active ingredients Salicylates: Acetylsalicylic acid 100 mg (Aspirin Cardio). P2Y12 antagonists: Clopidogrel (Plavix, generics). Prasugrel (Efient) Ticagrelor (Brilique) GP IIb/IIIa antagonists: Abciximab (ReoPro) Eptifibatide (Integrilin) Tirofiban (Aggrastat) PAR-1 antagonists: Vorapaxar (Zontivity) Vitamin K antagonists (coumarins): Phenprocoumon (Marcoumar). Acenocoumarol (Sintrom) Not on sale in many countries: dicoumarol, warfarin. Heparins: Heparin sodium Heparin-Calcium … Antithrombotics
Products Dabigatran is commercially available in capsule form (Pradaxa). It has been approved in many countries since 2012. It was first approved in 2008. Structure and properties Dabigatran (C25H25N7O3, Mr = 471.5 g/mol) is present in drugs as mesilate and in the form of the prodrug dabigatran etexilate, which is metabolized in the organism by … Dabigatran
Products Ticagrelor is commercially available in the form of film-coated tablets (Brilique). The active ingredient was approved in many countries in 2011. In 2018, additional meltable tablets were registered. Structure and properties Ticagrelor (C23H28F2N6O4S, Mr = 522.6 g/mol) is a cyclopentyltriazolopyrimidine without a thienopyridine structure. Ticagrelor is directly active. It has an active metabolite but, … Ticagrelor
Effects P2Y12 antagonists are antiplatelet agents and prevent the formation of blood clots. The effects are due to binding to the adenosine diphosphate receptor P2Y12 on platelets. This receptor plays a central role in glycoprotein (GP)-IIb/IIa activation and platelet aggregation. The continuous binding of adenosine diphosphate (ADP) to P2Y12 is an important prerequisite for thrombus … P2Y12 Antagonists
