Products
Clobetasol propionate is commercially available as cream, ointment, foam, shampoo, and scalp application (Dermovate, Clobex, Clarelux). It has been approved in many countries since 1976.
Structure and properties
Clobetasol propionate (C25H32ClFO5, Mr = 466.97 g/mol) is the ester of clobetasol with propionic acid. It is a derivative of prednisolone. Clobetasol propionate exists as a white crystalline powder that is insoluble in water.
Effects
Clobetasol propionate (ATC D07AD01) has anti-inflammatory, antipruritic, immunosuppressive, vasoconstrictive, and antiallergic properties. Clobetasol propionate is one of the very potent topical glucocorticoids (strength class IV). The effects are based on binding to intracellular glucocorticoid receptors in the cytoplasm of cells. The resulting complex interacts with DNA.
Indications
For the treatment of skin conditions that respond to topical glucocorticoids. The liquid dosage forms are used to treat eczema and psoriasis of the scalp.
Dosage
According to the SmPC. The medicines are usually applied thinly once or twice daily. Dermocorticoids are not suitable for uninterrupted long-term treatment.
Contraindications
- Hypersensitivity
- Rosacea
- Acne
- Itching without inflammation
- Perianal or genital pruritus
- Perioral dermatitis
- Skin ulcers
- Skin lesions caused primarily by bacteria
- Fungal infections
- Viral infections
- Vaccination reactions
- Children under 1 year
Full precautions can be found in the drug label.
Interactions
CYP3A4 inhibitors inhibit the metabolism of clobetasol propionate and may result in increased systemic exposure.
Adverse effects
The most common potential adverse effects include local skin reactions such as a burning sensation, pain, and itching. Inappropriate and overdosed use may result in skin lesions such as skin thinning, striae, and telangiectasias, as well as systemic glucocorticoid side effects.
