Trazodone: Effects, Application, Side Effect

How trazodone works The active ingredient trazodone interferes with the brain’s neurotransmitter metabolism: The nerve cells (neurons) in the brain communicate with each other with the help of various messenger substances (neurotransmitters). A cell can release a specific messenger substance, which then binds to specific docking sites (receptors) on the target cell and thus transmits … Trazodone: Effects, Application, Side Effect

Off-Label Use

Definition In drug therapy, “off-label use” refers to deviations from the officially approved specifications in the drug information leaflet of approved drugs that are ready for use. Frequently, this concerns the areas of application (indications). However, other changes also fall under the definition, for example with regard to the dose, duration of therapy, patient groups, … Off-Label Use

Aphrodisiacs

Effects Aphrodisiac Medical indications To promote sex drive or potency. Erectile dysfunction in men “Hypoactive Sexual Desire Disorder” (decreased sexual drive). Active ingredients Use v.a. in erectile dysfunction: phosphodiesterase-5 inhibitors increase blood flow to the corpus cavernosum of the penis and act only during sexual stimulation: Sildenafil (Viagra) Tadalafil (Cialis) Vardenafil (Levitra) Prostaglandins must be … Aphrodisiacs

Sleeping Pills: Effects, Side Effects, Dosage and Uses

Products Sleeping pills are most commonly taken in the form of tablets (“sleeping pills“). In addition, melting tablets, injectables, drops, teas and tinctures are also available, among others. The technical term hypnotics is derived from Hypnos, the Greek god of sleep. Structure and properties Within the sleeping pills, groups can be identified which have a … Sleeping Pills: Effects, Side Effects, Dosage and Uses

Antidepressants

Products Most antidepressants are commercially available in the form of film-coated tablets. In addition, oral solutions (drops), meltable tablets, dispersible tablets, and injectables are also available, among others. The first representatives were developed in the 1950s. It was discovered that the antituberculosis drugs isoniazid and iproniazid (Marsilid, Roche) had antidepressant properties. Both agents are MAO … Antidepressants

Nefazodon

Products Nefazodone was commercially available in tablet form in many countries beginning in 1997 (Nefadar, 100 mg, Bristol Myers Squibb). It was withdrawn from the market again in 2003 because of potential health risks. Structure and properties Nefazodone (C25H32ClN5O2, Mr = 470.0 g/mol) is present in drugs as nefazodone hydrochloride, a white crystalline powder that … Nefazodon

Trazodone

Products Trazodone is commercially available in the form of film-coated tablets and sustained-release tablets (Trittico, Trittico retard, Trittico Uno). The active ingredient was developed at Angelini in Italy in 1966 and has been approved in many countries since 1985. Auto-generics and generics are registered. Generic versions of the 100 mg film-coated tablets first went on … Trazodone

Diffuse Esophageal Spasm

Symptoms Diffuse esophageal spasm manifests as seizure-like pain behind the breastbone (chest pain) and difficulty swallowing. The pain may radiate to the arms and jaw, similar to angina. Other possible symptoms include shortness of breath, cramping and burning. The duration of attacks varies, ranging from seconds to minutes. They are often triggered by food intake, … Diffuse Esophageal Spasm

Serotonin Syndrome: Causes and Treatment

Background Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter biosynthesized from the amino acid tryptophan by decarboxylation and hydroxylation. It binds to seven different families of the serotonin receptor (5-HT1 to 5-HT7) and elicits central and peripheral effects that affect mood, behavior, sleep-wake cycle, thermoregulation, pain perception, appetite, vomiting, muscles, and nerves, among others. Serotonin is vasoconstrictive … Serotonin Syndrome: Causes and Treatment

Sleep Disorders

Symptoms Sleep disorder refers to an undesirable change in the usual sleep rhythm. This manifests itself in difficulty falling asleep or staying asleep, insomnia, a change in sleep profile, sleep length, or inadequate rest. Sufferers are unable to fall asleep for long periods in the evening, wake up at night or early in the morning, … Sleep Disorders

Trazodone: Effects, Uses & Risks

Trazodone is the name of a drug used to treat depression. In addition, the drug develops a calming effect. What is trazodone? Trazodone is the name of a drug used to treat depression. Trazodone belongs to the group of psychotropic drugs. Thus, the drug is used as an antidepressant and sedative. The active substance was … Trazodone: Effects, Uses & Risks