Valproate: Effects, Uses & Risks

Valproate is widely used in medicine to prevent seizures in epilepsy. In addition, it is often used as a phase prophylactic in bipolar disorder and schizoaffective psychosis. What is valproate? Valproate is widely used in medicine to prevent seizures in epilepsy. Valproates are salts of artificially produced valproic acid, which chemically belongs to the branched … Valproate: Effects, Uses & Risks

Lesinurad

Products Lesinurad was approved in the US in 2015, in the EU in 2016, and in many countries in 2017 in film-coated tablet form (Zurampic). A fixed-dose combination with allopurinol was released in the US in 2017 (Duzallo), in the EU in 2018, and in many countries in 2019. Structure and properties Lesinurad (C17H14BrN3O2S, Mr … Lesinurad

Lorazepam

Products Lorazepam is commercially available as tablets, meltable tablets, and a solution for injection. In addition to the original Temesta, generics and a combination product with the sedative antihistamine diphenhydramine are also available (Somnium). Lorazepam has been approved in many countries since 1973. Structure and properties Lorazepam (C15H10Cl2N2O2, Mr = 321.2 g/mol) is a white … Lorazepam

Migraine Headache

Symptoms Migraine occurs in attacks. It may announce itself up to three days before an attack with various precursors (prodromes). These include, for example: Mood changes Fatigue Hunger Frequent yawning Irritability Aura may occur before the headache phase in up to about one-third of patients: Visual disturbances such as flickering lights, dots or lines, facial … Migraine Headache

Serotonin Syndrome: Causes and Treatment

Background Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter biosynthesized from the amino acid tryptophan by decarboxylation and hydroxylation. It binds to seven different families of the serotonin receptor (5-HT1 to 5-HT7) and elicits central and peripheral effects that affect mood, behavior, sleep-wake cycle, thermoregulation, pain perception, appetite, vomiting, muscles, and nerves, among others. Serotonin is vasoconstrictive … Serotonin Syndrome: Causes and Treatment

What side effects can occur during discontinuation? | What are the side effects of valproic acid?

What side effects can occur during discontinuation? Medication should never be discontinued by the patient on their own, but always in consultation with a doctor. Sometimes side effects make it necessary to discontinue the antiepileptic drug. Regardless of this, discontinuation of the drug can be considered even after the recommended two-year seizure-free period.In any case, … What side effects can occur during discontinuation? | What are the side effects of valproic acid?