Products
Trientine was approved in many countries in 2020 in capsule form (Triogen).
Structure and properties
Trientine is present in the drug as trientine dihydrochloride, a white to slightly yellow hygroscopic powder that is readily soluble in water. It is triethylenetetramine.
Effects
Trientine (ATC A16AX12) forms a stable and soluble complex with copper. It promotes its excretion through the kidneys in the urine.
Indications
For the treatment of copper storage disease (Wilson’s disease) in patients who cannot tolerate treatment with D-penicillamine.
Dosage
According to the SmPC. Capsules are taken in 2 to 4 single doses 30 minutes to 1 hour before meals.
Contraindications
- Hypersensitivity
For complete precautions, see the drug label.
Interactions
Trientine lowers serum iron concentrations.
Adverse effects
Possible adverse effects include:
- Nausea
- Skin rash
- Duodenitis, severe colitis
- Anemia
- Neurological deterioration
