Congenital malformations, deformities, and chromosomal abnormalities (Q00-Q99).
- Netherton syndrome (synonym: Comèl-Netherton syndrome) -genetic skin disease (genodermatosis) with autosomal recessive inheritance; main features are ichthyosiform erythroderma (CIE), a distinct defect of the hair shaft (trichorrhexis invaginata; TI; bamboo hair), and atopy symptoms
- Wiskott-Aldrich syndrome – X-linked recessive inherited disorder with insufficiency (weakness) of blood clotting and immune system; symptom triad: eczema (rash), thrombocytopenia (lack of platelets), and recurrent infections
Blood, blood-forming organs – immune system (D50-D90).
- Hyper-IgE syndrome (HIES; synonyms: Job syndrome, hyperimmunoglobulin E syndrome) – rare primary immunodeficiency with autosomal dominant inheritance characterized by the following clinical triad (trinity):
- Eczema with excessively elevated serum IgE (> 2,000 IU/ml).
- Recurrent staphylococcal abscesses of the skin.
- Pneumonias (pneumonia)
Other symptoms include: increased bone fragility, hyperextensibility of joints, scoliosis, persistence of deciduous teeth (multisystem disease).
- Omenn syndrome (OS) – genetic disorder with autosomal recessive inheritance; characterized by inflammatory disease with erythroderma (extensive skin redness), scaling, alopecia (hair loss), chronic diarrhea (diarrhea), failure to thrive, lymphadenopathy (lymph node enlargement), and hepatosplenomegaly (liver and spleen enlargement); Severe combined immunodeficiency (immune deficiency) with hypereosinophilia (increase in eosinophilic granulocytes in peripheral blood).
Skin and subcutaneous (L00-L99).
- Allergic eczema (allergic contact dermatitis) – skin reactions triggered by allergens.
- Irritant eczema (irritant contact eczema) – reactions triggered by irritants to the skin.
- Microbial eczema – skin reactions triggered by bacteria.
- Psoriasis (psoriasis) palmoplantaris (palm) – demarcation of hand eczema.
- Seborrheic dermatitis – greasy-scaly skin inflammation.
- Scabies (scabies)
- Tinea manuum et pedum (fungal disease of the hands and feet) – demarcation of hand and foot eczema.
Neoplasms – tumor diseases (C00-D48).
- Cutaneous T-cell lymphoma (of which the early eczema stage) [in adults].