Chagas Disease (American Trypanosomiasis): Drug Therapy Therapeutic targets Rehydration (fluid balance). Elimination of pathogens Avoidance of complications Therapy recommendations In the acute phase: antiprotozoal agents. Rehydration – oral rehydration for signs of dehydration (fluid deficiency; > 3% weight loss): administration of oral rehydration solutions (ORL), which should be hypotonic, between meals (“tea breaks”) for mild to moderate dehydration. Compensation of electrolyte losses (blood salts). In the chronic phase, only symptomatic therapy can be performed.