Products
Dolocyl cream containing 5% ibuprofen was approved in many countries in 2015 and has been on the market since March 2016. Ibuprofen gels were previously available.
Structure and properties
Ibuprofen (C13H18O2, Mr = 206.3 g/mol) belongs to the propionic acid derivative group and is a racemate. It exists as a white crystalline powder or as crystals and is practically insoluble in water.
Effects
Ibuprofen (ATC M02AA13) has analgesic and anti-inflammatory properties. The effects are due to inhibition of prostaglandin synthesis by inhibition of the enzyme cyclooxygenase. Ibuprofen passes from the cream locally into the tissues, but is hardly absorbed – only about five percent – into the blood. The dosage form has additional skin-care effects and does not dry out the skin like a gel.
Indications
For the external treatment of pain, inflammation, and swelling, for example, in sports injuries (sprains, bruises, strains) and rheumatic complaints of the musculoskeletal system. For patients 14 years of age and older.
Dosage
According to the professional information. The cream is applied three to four times daily and rubbed in gently.
Contraindications
The cream is contraindicated in case of hypersensitivity (including to acetylsalicylic acid and other NSAIDs). It should not be used by children under 14 years of age, during the last trimester of pregnancy, and while breastfeeding. For complete precautions, see the drug label.
Interactions
Drug-drug interactions are not known.
Adverse effects
Possible adverse effects include local reactions such as skin redness, itching, a tingling sensation, a rash, and hypersensitivity reactions. The risk of systemic side effects is low when used properly. The cream acts locally and is therefore better tolerated than ibuprofen tablets.