Amikacin

Products

Amikacin is commercially available as a solution for injection (Amikin). It has been approved in many countries since 1976.

Structure and properties

Amikacin (C₂₂H₄₃N₅O₁₃, M_r = 585.6 g/mol) is semisynthetically prepared from kanamycin A. It is found in drugs as amikacin sulfate, a white powder that is readily soluble in water.

Effects

Amikacin (ATC J01GB06) has bactericidal properties against Gram-positive and Gram-negative pathogens. The effects are based on binding to the 30S subunit of bacterial ribosomes. This interferes with protein synthesis.

Indications

For short-term treatment of bacterial infectious diseases with susceptible pathogens.

Dosage

According to the SmPC. The drug is mainly injected as an intravenous or intramuscular injection.

Contraindications

• Hypersensitivity

For complete precautions, see the drug label.

Adverse effects

The most common potential adverse effects include oto- and nephrotoxicity. Amikacin may cause hearing loss, balance disturbances, and a reduction in renal function.