Amsacrine

Products

Amsacrine is commercially available as an infusion preparation (Amsidyl). It has been approved in many countries since 1993.

Structure and properties

Amsacrine (C₂₁H₁₉N₃O₃S, M_r = 393.5 g/mol) is an aminoacridine derivative.

Effects

Amsacrine (ATC L01XX01) has antineoplastic properties. The effects are due to inhibition of topoisomerase II. As a result, DNA synthesis is blocked.

Indications

For the treatment of acute myeloid and acute lymphoblastic leukemia.

Dosage

According to the SmPC. The drug is administered as an intravenous infusion.

Contraindications

• Hypersensitivity
• Severe bone marrow suppression
• Pregnancy and lactation

Full precautions can be found in the drug label.

Adverse effects

The most common possible adverse effects include hair loss, purpura, fever, phlebitis, low blood pressure, bone marrow suppression, nausea, vomiting, diarrhea, abdominal pain, oral mucositis, and esophagitis.