Products
Calcium carbasalate (carbasalate calcium) is commercially available in the form of tablets and effervescent tablets (Alcacyl, Alca C with vitamin C). It has been approved in many countries since 1935. Note: Alcacyl powder contains lysine acetyl salicylate.
Structure and properties
Calcium carbasalate (C19H18CaN2O9, Mr = 458.4 g/mol) exists as a white crystalline powder that is readily soluble in water. It is a calcium salt of acetylsalicylic acid (aspirin) containing urea (carbamide). Calcium carbasalate is rapidly metabolized in the body to salicylic acid. It is more water soluble than acetylsalicylic acid and is absorbed more quickly.
Effects
Calcium carbasalate (ATC N02BA65) has analgesic, antipyretic, anti-inflammatory, and antiplatelet properties. The effects are due to inhibition of cyclooxygenase and inhibition of prostaglandin biosynthesis. Calcium carbasalate has a short half-life of two to three hours.
Indications
For the treatment of pain and fever of various causes, e.g., colds.
Dosage
According to the professional information. Medicines are usually taken every 4 to 8 hours and after meals.
Contraindications
Numerous precautions and drug-drug interactions must be observed during use. Full details can be found in the drug label.
Adverse effects
The most common possible adverse effects include microbleeding, stomach upset, dyspepsia, nausea, and vomiting. Calcium carbasalate, like all NSAIDs and acetylsalicylic acid, can rarely cause serious adverse reactions, such as allergic reactions, gastric and intestinal ulcers, and renal dysfunction.
