Products
Cathinone is not approved as a drug in many countries and is therefore not commercially available. It is one of the banned narcotics (d). In recent years, there have been increasing reports of synthetic cathinone derivatives (designer drugs) such as mephedrone and MDPV, which were initially sold legally as fertilizer and bath salts. Legislation has since been adjusted and many of these substances have also been banned.
Structure and properties
Cathinone (C9H11NO, Mr = 149.2 g/mol) is structurally closely related to amphetamine but differs in the keto group and is therefore also known as β-ketoamphetamine. Cathinone is a racemate, with D-cathinone being pharmacologically more active. The alkaloid occurs naturally in cath, a stimulant and stimulant consumed mainly in East Africa and the Arabian Peninsula.
Effects
Cathinone has centrally stimulating, sympathomimetic, euphoric, and psychotropic properties. The effects are due to reuptake inhibition and neurotransmitter release, resulting in increased concentration and enhanced effects. In this regard, pure cathinone has a more potent effect than cath.
Indications for use
Currently, cathinone is not approved for medical indications. It is abused as an intoxicant (party drug, “club drug”) and smart drug and used as a stimulant in the form of cath.
Adverse effects
Cathinone abuse is not advised due to the sometimes life-threatening side effects. Possible adverse effects include:
- Central and psychiatric disorders, e.g., irritability, insomnia, psychosis, restlessness, agitation, dizziness, hallucinations, dependence
- Cardiovascular disorders: Hypertension, rapid or slow pulse, heart attack, chest pain, cerebral hemorrhage.
- Digestive disorders: Lack of appetite, nausea, vomiting, dry mouth.
