Products
Dimetinden maleate is available as oral drops (Feniallerg drops). They were formerly called Fenistil drops. The drug has been approved in many countries since 1961.
Structure and properties
Dimetindene (C20H24N2, Mr = 292.4 g/mol) is present in drugs as dimetindene maleate, a white crystalline powder that is poorly soluble in water. The name is derived from the two methyl groups on the nitrogen and the central indene ring. Dimetindene is a racemate.
Effects
Dimetindene maleate (ATC R06AB03) has antihistamine, antiallergic, anticholinergic, antipruritic, depressant, and local anesthetic properties. The effects are based on antagonism at histamine H1 receptors and mast cell stabilization. Unlike modern antihistamines, dimetindene is less selective. The half-life is 6 hours. Effects occur after approximately 30 minutes.
Indications
- For symptomatic treatment of allergic diseases, for example, hay fever and urticaria.
- For the treatment of itching of various origins, for example, chickenpox.
- For additional treatment in eczema and other itchy skin diseases of allergic origin.
- Off-label: nausea, vomiting, motion sickness.
Dosage
According to the professional information. The drops are usually taken three times a day. The dose is based on age or body weight. Caution: the drops are sensitive to heat and therefore should not be mixed with a hot drink.
Abuse
Dimetinden maleate can theoretically be abused as a sedating narcotic.
Contraindications
- Hypersensitivity
- Neonates under 1 month of age, especially premature infants
- Use in infants only after consultation with a physician / a doctor
Full precautions can be found in the drug label.
Interactions
Drug interactions are possible with central depressant drugs and alcohol.
Adverse effects
The most common possible adverse effects include fatigue, drowsiness, and nervousness.
