The drug Atosil® can be taken both as drops and as tablets. In both cases the active ingredient is promethazine. This blocks the body’s histamine receptors and thus inhibits signaling pathways that are responsible for allergic processes or increased activity.
However, Atosil® in drop form is nowadays used almost exclusively for restlessness, states of excitement and rarely for sleep disorders, as the newer drugs used in the therapy of allergies have fewer side effects. Atosil® drops can also be used to treat nausea and vomiting. If Atosil® is taken in the form of drops, the quantity can be dosed more accurately, as it is much more difficult to divide one tablet than, for example, 20 drops.
Even small changes, such as two additional drops, can therefore adjust the effect more precisely to the individual patient. In addition, the drops do not have to dissolve in the stomach first in order to be absorbed and can therefore act faster. The dosage depends on the underlying disease and the severity of the illness.
For adults, the dosage is between 20 and only for very severe diseases up to a maximum of 120 drops per day. Children under 18 years of age should start with a starting dose of 10 drops and increase this to a maximum of two drops per kilogram of body weight if necessary. However, the dosage should always be discussed with a doctor.
When are 25mg taken?
There are various indications for treatment with 25mg Atosil®, which corresponds to approx. 25 drops. On the one hand, this dosage is used as a starting dose in adults for the treatment of agitation and agitation states.
Another indication of this dosage may be sleep disorders. Here the 25mg Atosil® are taken before going to bed. On the other hand this dose is indicated for complaints such as nausea and vomiting. For all these indications, the dose should be adjusted individually depending on the severity of the complaints, age, height and weight of the patient.
Entry into effect
The onset of action of Atosil® is about 20 minutes after ingestion. Among other things, it depends on how long ago the last meal was and whether food is taken before it is the turn of the active ingredient of Atosil®. In addition, Atosil® in drop form is absorbed somewhat earlier, since it is partially absorbed by the oral mucosa and, unlike tablets, does not have to dissolve in the stomach first.
After the onset of action, the effect of Atosil® usually lasts four to six hours. As an antiallergic, the biggest side effects are fatigue and sedation. As a result, driving a car and performing dangerous tasks requiring concentration should not be performed.
Due to the effect on other receptors, taking Atosil® leads to dry mouth, difficulty in urination, as well as dilation of pupils, gastrointestinal complaints such as nausea, vomiting or constipation and accelerated heart rate. For this reason, treatment with Atosil® should be monitored by a physician. These side effects are similar to the symptoms of atropine poisoning and actually only occur at too high toxic doses.
It can also lower blood pressure. Atosil® also influences sexual and pleasure behavior, which is thereby reduced. In children, Atosil® can have a paradoxical effect compared to adults, in that central arousal rather than sedation occurs.
Since Atosil® is a neuroleptic, it should be noted that the drug has a potential for dependence. However, which side effects can occur and to what extent, generally depends on the dosage form in which Atosil® is administered:
- Tablet and
- Other shapes. When taking Atosil® , side effects on the skin occur only occasionally.
This means that this side effect occurs in one in 100 to 1000 cases. In addition to skin abnormalities, itching may also occur. This is due to the fact that Atosil® influences various signaling pathways which are activated in allergies, among other things, and are often associated with itching.
On the one hand, the calming effect, which also reduces activity and thus energy consumption, can lead to weight gain when taking Atosil®. On the other hand, Atosil® has an effect on various messenger substances in the brain that are responsible for regulating appetite and fat metabolism. For example, leptin is a hormone that is responsible for the feeling of satiety and is produced by the fat cells when they eat.
The action of Atosil® blocks the pathways responsible for the feeling of satiety and thus promotes an increased feeling of hunger, which can lead to weight gain. Other messenger substances such as serotonin or histamine are also important for regulating appetite. Since Atosil® acts on the same receptors and thus alters these signaling pathways, a disturbed balance of satiation and appetite occurs.
Since the receptors described are differently pronounced in each person, weight gain also varies or does not occur at all. If weight gain is unintentional, however, the medication should not be discontinued, as sudden discontinuation can lead to side effects such as renewed or even increased symptoms. Instead, you should consult your doctor and discuss alternatives if necessary.
On the other hand, Atosil® may also lead to weight loss from time to time. This is because anxiety, restlessness and sleeping disorders are often the trigger for weight gain, which can be remedied by treatment with Atosil®. Both alcohol and Atosil® can have a calming effect when taken, but in higher doses they can even have an anaesthetic effect.
As both also act at central switch points of the body, they can influence and enhance each other’s effects. This can lead to confusion, concentration disorders, a drop in blood pressure or even unconsciousness. For this reason the simultaneous intake of Atosil® and alcohol is not tolerated and should be avoided at all costs.