Focal Segmental Sclerosing Glomerulonephritis

Focal Segmental Sclerosing Glomerulonephritis: Medical History

Medical history (history of illness) represents an important component in the diagnosis of focal segmental sclerosing glomerulonephritis. Family history Does your family have a history of kidney disease that is common? Are there any hereditary diseases in your family? Social anamnesis Current medical history/systemic medical history (somatic and psychological complaints). Have you gained body weight … Focal Segmental Sclerosing Glomerulonephritis: Medical History

Focal Segmental Sclerosing Glomerulonephritis: Or something else? Differential Diagnosis

Blood, hematopoietic organs-immune system (D50-D90). Schönlein-Henoch purpura (age <20 years). Genitourinary system (kidneys, urinary tract – reproductive organs) (N00-N99). Other forms of glomerulonephritis Benign familial hematuria (synonym: thin basement membrane nephropathy) – isolated, familial persistent glomerular hematuria (blood in the urine) and minimal proteinuria (excretion of protein in the urine) with normal renal function.

Focal Segmental Sclerosing Glomerulonephritis: Complications

The following are the most important diseases or complications that may be contributed to by focal segmental sclerosing glomerulonephritis: Genitourinary system (kidneys, urinary tract-genital organs) (N00-N99). Nephrotic syndrome – collective term for symptoms that occur in various diseases of the glomerulus (renal corpuscles); symptoms include: Proteinuria (excretion of protein in the urine) with protein loss … Focal Segmental Sclerosing Glomerulonephritis: Complications

Focal Segmental Sclerosing Glomerulonephritis: Examination

A comprehensive clinical examination is the basis for selecting further diagnostic steps: General physical examination – including blood pressure, pulse, body weight, height; further: Inspection (viewing). Skin and mucous membranes [leading symptoms: generalized edema (water retention occurring throughout the body); morning swelling of eyelids, face, lower legs] Auscultation (listening) of the heart. Auscultation of the … Focal Segmental Sclerosing Glomerulonephritis: Examination

Focal Segmental Sclerosing Glomerulonephritis: Test and Diagnosis

1st order laboratory parameters – obligatory laboratory tests. Small blood count Inflammatory parameters – CRP (C-reactive protein) or ESR (erythrocyte sedimentation rate). Urine status (rapid test for: pH, leukocytes, nitrite, protein, blood), sediment, if necessary urine culture (pathogen detection and resistogram, that is, testing of suitable antibiotics for sensitivity / resistance). Erythrocyte morphology (shape of … Focal Segmental Sclerosing Glomerulonephritis: Test and Diagnosis

Focal Segmental Sclerosing Glomerulonephritis: Micronutrient Therapy

An at-risk group indicates the possibility that the disease may be associated with the risk of vital nutrient (micronutrient) deficiency. The complaint nephrotic syndrome indicates vital nutrient (micronutrient) deficiency for: Calcium Iron Copper Zinc A risk group indicates the possibility that the disease may be associated with the risk of vital substance deficiency (micronutrients). The … Focal Segmental Sclerosing Glomerulonephritis: Micronutrient Therapy

Focal Segmental Sclerosing Glomerulonephritis: Symptoms, Complaints, Signs

The following symptoms and complaints may indicate focal segmental sclerosing glomerulonephritis: Leading symptoms Generalized edema – water retention occurring throughout the body. Proteinuria – increased excretion of protein in the urine. Hypoproteinemia – too little protein in the blood. Derailment of fat metabolism

Focal Segmental Sclerosing Glomerulonephritis: Causes

Pathogenesis (disease development) The exact mechanisms of the development of focal segmental sclerosing glomerulonephritis are not clear. A primary form can be distinguished from a secondary form. The triggers of the primary form are mutations in various renal genes, whereas those of the secondary form are diverse. Etiology (Causes) Biographic causes Genetic burden Genetic in … Focal Segmental Sclerosing Glomerulonephritis: Causes

Focal Segmental Sclerosing Glomerulonephritis: Therapy

General measures Nicotine restriction (refraining from tobacco use). Aim for normal weight!Determination of BMI (body mass index, body mass index) or body composition by means of electrical impedance analysis and, if necessary, participation in a medically supervised weight loss program or program for the underweight. Review of permanent medication due topossible effect on the existing … Focal Segmental Sclerosing Glomerulonephritis: Therapy

Focal Segmental Sclerosing Glomerulonephritis: Drug Therapy

Therapeutic target Avert deterioration of renal function Therapy recommendations Early initiation of immunosuppressive therapy: Glucocorticoids should be started first, as response to these can estimate prognosis Ciclosporin (cyclosporin A) is used in contraindications (contraindications) to glucocorticoids or steroid resistance. The immunosuppressant abatacept (rheumatoid drug) can stop proteinuria (increased excretion of protein in the urine) in … Focal Segmental Sclerosing Glomerulonephritis: Drug Therapy