Squamous Cell Carcinoma of the Skin: Causes
Pathogenesis (disease development) UV radiation, X-rays, and chemical carcinogens cause DNA damage to the skin (signature mutations). These are only partially repaired, so that mutations (changes in genetic material) lead to malignant proliferation (“malignant proliferation”) of keratinocytes (“horn-forming cells”) of the skin or skin appendages. Squamous cell carcinoma (PEC) of the skin usually develops on … Squamous Cell Carcinoma of the Skin: Causes