Medical history (history) is an important component in the diagnosis of squamous cell carcinoma of the skin (PEK). Family history Is there a frequent history of skin disease in your family? Social history What is your profession? Current medical history/systemic history (somatic and psychological complaints). What skin changes have you noticed? Please describe them. On … Squamous Cell Carcinoma of the Skin: Medical History
Skin and subcutaneous (L00-L99). Actinic keratosis – cornification disorder of the skin caused by radiation-especially UV radiation (precancerous; risk factor for squamous cell carcinoma). Arsenic keratosis – changes in the skin caused by chronic exposure to arsenic; this includes the yellowish discoloration and roughness and dryness. Chronic eczema Tinea corporis (synonym: ringworm) – dermatophytosis (infection … Squamous Cell Carcinoma of the Skin: Or something else? Differential Diagnosis
The following are the most important diseases or complications that can be caused by squamous cell carcinoma of the skin (PEK): Neoplasms – Tumor Diseases (C00-D48). Metastases, especially in lymph nodes or by direct infiltration. Basal cell carcinoma (BCC; basal cell carcinoma) as a secondary tumor after a PEK of the skin. Tumors of other … Squamous Cell Carcinoma of the Skin: Complications
Classification of squamous cell carcinoma according to UICC TNM. T1 Tumor ≤ 2 cm in greatest horizontal extent. T2 Tumor > 2 cm in greatest horizontal extent T3 Infiltration of deep extradermal structures (skeletal muscle, cartilage, bone, jaws, and orbits) T4 Infiltration of the base of the skull or the axial skeleton Nx Regional lymph … Squamous Cell Carcinoma of the Skin: Classification
A comprehensive clinical examination is the basis for selecting further diagnostic steps: General physical examination – including blood pressure, pulse, body weight, height; further: Inspection (viewing) of the skin, mucous membranes, and sclera (white part of the eye) [inconspicuous plaques, usually skin-colored, that develop into a raised hard tumor due to an inflammatory reaction; this … Squamous Cell Carcinoma of the Skin: Examination
1st order laboratory parameters Biopsy (tissue sampling) of the lesion: confirm the diagnosis by histology (fine tissue examination) in H/E section (hematoxylin-eosin stain)Note: Preoperatively, the maximum longitudinal diameter of the lesion should be determined. Complete resection (complete surgical removal). Notes on obtaining histology Depending on the clinical situation, punch biopsies, shallow ablations (“shave” excisions), or … Squamous Cell Carcinoma of the Skin: Test and Diagnosis
Therapeutic target Improvement of prognosis Therapy recommendations First-line therapy: complete excision (excision in toto; removal of the skin lesion in healthy tissue), with sentinel lymph node biopsy (SLND; sentinel lymph node removal) if necessary. Metastatic or unresectable squamous cell carcinoma of the skin (PEK of the skin). Cytostatic therapy (cisplatin + 5-fluorouracil (5-FU)), alternatively monotherapy … Squamous Cell Carcinoma of the Skin: Drug Therapy
Optional medical device diagnostics – depending on the results of the history, physical examination, laboratory diagnostics, and obligatory medical device diagnostics – for differential diagnostic clarification. Dermatoscopy (reflected light microscopy; increases diagnostic confidence). Fluorescence diagnostics (FD; synonym: photodynamic diagnostics, PDD); for in vivo diagnosis of non-melanocytic tumors such as basal cell carcinomas or squamous cell … Squamous Cell Carcinoma of the Skin: Diagnostic Tests
Squamous cell carcinoma of the skin (cutaneous squamous cell carcinoma; CSCC) is curable (“curative”) in up to 95% by surgery. 1st order Complete excision (excision in toto; surgical removal of the skin lesion in healthy tissue; R0 resection) with histologic incision margin control (per micrographic controlled surgery (MKC) with three-dimensional histologic (fine tissue) evaluation of … Squamous Cell Carcinoma of the Skin: Surgical Therapy
To prevent squamous cell carcinoma of the skin (PEK), attention must be paid to reducing individual risk factors. Behavioral risk factors Stimulants Alcohol – dose-dependent association: with each glass of alcohol drunk daily, risk increased by an additional 22%; Men: > 20 g alcohol per day significant risk increase (+ 33%). Women: 5.0-9.9 g alcohol … Squamous Cell Carcinoma of the Skin: Prevention
Radiotherapy (radiation therapy) should be performed for tumors that are not locally resectable in sano (removal in healthy tissue) or inoperable. Postoperative radiotherapy should be performed for: R1- (macroscopically, the tumor was removed; however, histopathology demonstrates smaller portions of the tumor in the resection margin) or R2-resection/larger, macroscopically visible portions of the tumor could not … Squamous Cell Carcinoma of the Skin: Radiotherapy
The following symptoms and complaints may indicate squamous cell carcinoma of the skin (PEK): Inconspicuous, usually skin-colored hyperkeratotic (“highly keratinizing”) papules (nodules) and plaques (areal or squamous substance proliferation of the skin), usually covered with adherent scaling; development into a raised hard tumor by an inflammatory reaction; also possible is a flat ulcer (ulcer) with … Squamous Cell Carcinoma of the Skin: Symptoms, Complaints, Signs
