Products Tiagabine was commercially available in the form of film-coated tablets (gabitril). It was approved in many countries in 1996 and went off the market in June 2012. Structure and properties Tiagabine (C20H25NO2S2, Mr = 375.5 g/mol) is a piperidine and thiophene derivative. It exists as a white crystalline powder that is sparingly soluble in … Tiagabine
Products Perampanel is commercially available in the form of film-coated tablets (Fycompa). It has been approved in many countries since late 2012. In 2020, an oral suspension was also registered. Structure and properties Perampanel (C23H15N3O, Mr = 349.4 g/mol) is a pyridine derivative. It exists in the drug as a white to yellowish powder that … Perampanel
Products Rufinamide is commercially available as film-coated tablets and as an oral suspension (Inovelon). It was approved in the EU in 2007 and in many countries in 2009. The suspension was registered in many countries in 2012. Structure and properties Rufinamide (C10H8F2N4O, Mr = 238.2 g/mol) is a methyl triazole carboxamide. It exists as a … Rufinamide
Products Primidone is commercially available in tablet form (Mysoline). It has been approved in many countries since 1952. Structure and properties Primidone (C12H14N2O2, Mr = 218.3 g/mol) is a white crystalline powder that is very sparingly soluble in water. Effects Primidone (ATC N03AA03) has antiepileptic properties. Indications Grand mal, psychomotor epilepsy, focal seizures, petit mal, … Primidone
Products Vigabatrin is commercially available as film-coated tablets and as a powder (Sabril). It has been approved in many countries since 1992. Structure and properties Vigabatrin (C6H11NO2, Mr = 129.2 g/mol) is structurally a GABA analog. It exists as a white powder that is readily soluble in water. Effects Vigabatrin (ATC N03AG04) has antiepileptic properties. … Vigabatrin
Products Levetiracetam is commercially available as film-coated tablets, an oral solution, and an infusion concentrate (Keppra, generics). It has been approved in many countries since 2000 (United States: 1999). Starting in 2011, generics and new dosage forms entered the market (minipacks). Brivaracetam (Briviact) was developed by UCB as its successor. Structure and properties Levetiracetam (C8H14N2O2, … Levetiracetam
Products Lacosamide is commercially available as film-coated tablets, syrup, and infusion solution (Vimpat). It has been approved in many countries since 2009. Structure and properties Lacosamide (C13H18N2O3, Mr = 250.3 g/mol) is present as a white to slightly yellow powder and is sparingly soluble in water. It is present in the drug as a pure … Lacosamide
Products Ethosuximide is commercially available in the form of capsules (Petinimid). It has been approved in many countries since 1963. Structure and properties Ethosuximide (C7H11NO2, Mr = 141.2 g/mol) is a racemate. It exists as a white powder or waxy mass and is readily soluble in water. Indication For the treatment of minor epileptic seizures … Ethosuximide
Products Topiramate is commercially available in tablet and capsule form (Topamax, generic). It has been approved in many countries and in the United States since 1996. Structure and properties Topiramate (C12H21NO8S, Mr = 339.36 g/mol) lies as a white powder with a bitter taste that is soluble in water. It is a sulfamate-substituted monosaccharide. Effects … Topiramate
Products Gabapentin is commercially available in the form of capsules and film-coated tablets (Neurontin, generic). It has been approved in many countries since 1994. Pfizer launched pregabalin (Lyrica) as its successor in 2004. Structure and properties Gabapentin (C 9 H 17 NO 2 , M r = 171.2 g/mol) is structurally a GABA analog and … Gabapentin: Drug Effects, Side Effects, Dosage and Uses
Products Lamotrigine is commercially available as tablets and dispersible or chewable tablets (Lamictal, generics). It has been approved in many countries since 1994. Vanillin is typically added to the tablets as a flavoring agent and saccharin as a sweetener. Structure and properties Lamotrigine (C9H7Cl2N5, Mr = 256.1 g/mol) is a chlorinated phenyltriazine derivative that was … Lamotrigine (Lamictal)
Product Phenytoin is commercially available in tablet, injection, and infusion forms (phenhydane, phenytoin gerot). It has been approved in many countries since 1960. Structure and properties Phenytoin or 5,5-diphenylhydantoin (C15H12N2O2, Mr = 252.3 g/mol) exists as a white crystalline powder that is practically insoluble in water. The sodium salt phenytoin sodium, which is present in … Phenytoin: Drug Effects, Side Effects, Dosage and Uses
