Products Zonisamide is commercially available in the form of capsules (Zonegran). It has been approved in many countries since 2006. Structure and properties Zonisamide (C8H8N2O3S, Mr = 212.2 g/mol) is a benzisoxazole derivative and a sulfonamide. It exists as a white powder that is soluble in water. Effects Zonisamide (ATC N03AX15) has anticonvulsant and antiepileptic … Zonisamide
Products Oxcarbazepine is available in the form of film-coated tablets, sustained-release tablets, and as a suspension and commercially (Trileptal, Apydan extent). It has been approved in many countries since 1997. Structure and properties Oxcarbazepine (C15H12N2O2, Mr = 252.3 g/mol) exists as a white to faint orange crystalline powder and is practically insoluble in water. Oxcarbazepine … Oxcarbazepine
Products Retigabine was approved in many countries as film-coated tablets since 2011 (Trobalt). In the United States, it is referred to as ezogabine. It was discontinued in 2017. Structure Retigabine (C16H18FN3O2, Mr = 303.3 g/mol) is a carbamate that was developed starting from the analgesic flupirtine. The free primary amino group is -glucuronidated (see below). … Retigabine (Ezogabine)
Products Sultiam is commercially available in the form of film-coated tablets (Ospolot). It has been approved in many countries since 2003. In Germany, it was approved as early as 1998. In English, it is also referred to as resp. Structure and properties Sultiam (C10H14N2O4S2, Mr = 290.4 g/mol) is a sulfonamide derivative that is structurally … Sultiam
Products Potassium bromide is commercially available in Germany in the form of 850 mg tablets (Dibro-Be Mono). In many countries, apart from alternative medicine preparations, no medicines containing potassium bromide are currently available. The drugs can be imported or possibly prepared as an extemporaneous formulation. Kalium bromatum is the Schüssler salt no. 14. Structure and … Potassium Bromide
Products Valproic acid is commercially available as tablets, mini-tablets (minipacks), capsules, injectable, syrup, and solution (Depakine, generic). It has been approved in many countries since 1972. Structure and properties Valproic acid (C8H16O2, Mr = 144.2 g/mol) or 2-propylpentanoic acid is a colorless to slightly yellowish, clear, and slightly viscous liquid that is very slightly soluble … Valproic Acid: Drug Effects, Side Effects, Dosage and Uses
Products Pregabalin is commercially available in capsule form and as an oral solution (Lyrica, generics). It was approved in the United States and EU in 2004 and in many countries in 2005. Structure and properties Pregabalin (C8H17NO2, Mr = 159.2 g/mol) exists as a white crystalline powder that is soluble in water. It was developed … Pregabalin
Products Carbamazepine is commercially available as tablets, sustained-release tablets, suspension, and syrup (Tegretol, generics). It has been approved in many countries since 1963. Structure and properties Carbamazepine (C15H12N2O, Mr = 236.3 g/mol) exists as a white crystalline powder that is very sparingly soluble in water. It has a tricyclic structure and an active metabolite, carbmazepine-10,11-epoxide. … Carbamazepine Effects and Side Effects
Products Felbamate is commercially available in tablet and suspension form (Taloxa). It has been approved in many countries since 1997. Structure and properties Felbamate (C11H14N2O4, Mr = 238.2 g/mol) is a dicarbamate. It exists as a white crystalline powder with a typical odor that is sparingly soluble in water. Effects Felbamate (ATC N03AX10) has antiepileptic … Felbamate
Products Brivaracetam was approved in the EU, the United States, and many countries in 2016 in the form of film-coated tablets, oral solution, and solution for injection (Briviact). Structure and properties Brivaracetam (C11H20N2O2, Mr = 212.3 g/mol) is structurally and pharmacologically closely related to levetiracetam (Keppra, generics). Like levetiracetam, it is a pyrrolidinone derivative. Effects … Brivaracetam
Products Mesuximide is commercially available in the form of capsules (Petinutin). It has been approved in many countries since 1963. Structure and properties Mesuximide (C12H13NO2, Mr = 203.2 g/mol) belongs to the succinimides and exists as a racemate. The active metabolite -demethylmesuximide, with a long half-life of over 30 hours, is also involved in the … Mesuximide
Products Eslicarbazepine has been approved in tablet form in the EU since 2009, in the United States since 2013, and in many countries in 2020 (Zebinix, Aptiom). Structure and properties Eslicarbazepine (C15H14N2O2, Mr = 254.3 g/mol) is present in drugs in the form of the prodrug eslicarbazepine acetate, which is hydrolyzed in the body after … Eslicarbazepine
