Products No drugs containing benznidazole are on the market in many countries. Rochagan or Radanil are not approved in many countries. Structure and properties Benznidazole (C12H12N4O3, Mr = 260.2 g/mol) is a nitroimidazole and an acetamide. The compound was originally developed at Roche and launched in the 1970s. Effects Benznidazole (ATC P01CA02) has antiparasitic properties. … Benznidazole
Products Crotamiton was available in many countries as a cream and lotion for external use (Eurax). It was approved in 1946. In 2012, its distribution was discontinued. Structure and properties Crotamiton (C13H17NO, Mr = 203.3 g/mol) exists as a colorless to pale yellow, oily liquid with a slight amine odor. It is sparingly soluble in … Crotamiton
Effects Insecticidal Antiparasitic Ovicidal: killing eggs Larvicidal: larvae killing Partially insect repellent Indications Infestation by parasites, such as head lice and fleas. Active ingredients (selection) Allethrin Crotamiton (Eurax, out of trade). Disulfiram (Antabus, not commercially available for this indication). Flea medication Ivermectin (Stromectol, France) Lindane (Jacutin, out of trade). Malathion (Prioderm, out of trade) Mesulfen … Insecticides
Indications Antihelminthics are used to treat worm infections and, in some cases, protozoa. Active ingredients Imidazoles / benzimidazoles: Mebendazole (Vermox). Pyrantel (Cobantril) Other: Pyrvinium (Pyrcon, Molevac, Germany). Albendazole (Zentel) Aminoglycosides: Paromomycin (Humatin) Other: Ivermectin (Stromectol, import from France, in many countries not in the approved and not on sale). Niclosamide (not commercially available in many … Antihelminthics (Vermifuge)
Products Fexinidazole is about to be approved by the EMA in 2018 in tablet form (Fexinidazole Winthrop). This is the first new approval in this field in decades. For the first time, a peroral therapy is available. The drug has been developed since 2005 in a collaboration between DNDi (Drugs for Neglected Diseases initiative), Sanofi … Fexinidazole
Products Albendazole is commercially available as chewable tablets and as a suspension (zentel). It was approved in many countries in 1993. Structure and properties Albendazole (C12H15N3O2S, Mr = 265.3 g/mol) exists as a white to slightly yellowish powder that is practically insoluble in water. It is a benzimidazole derivative and is completely biotransformed after absorption. … Albendazole
Products Pentamidine is commercially available as a dry substance for injection or inhalation (pentacarinate). It has been approved in many countries since 1990. Structure and properties Pentamidine (C19H24N4O2, Mr = 340.4 g/mol) is an aromatic diamidine. It exists as a pentamidine diisetionate, a white powder or colorless crystals that are readily soluble in water. Effects … Pentamidine
Effects Antiparasitic against plasmodia. Indications Malaria Malaria prophylaxis Also for the treatment of rheumatic diseases, lupus erythematosus. Off-label: some antimalarials such as quinine and chloroquine are used off-label to treat calf cramps. Active ingredients Aminoquinolines: Amodiaquine Chloroquine (Nivaquine, out of commerce). Hydroxychloroquine (Plaquenil) Mepacrine Pamaquin Piperaquine Primaquine Tafenoquin (crinoline) Biguanides: Proguanil (Malarone + Atovaquone). Cycloguanilembonate … Antimalarials