Products Vaborbactam was approved in the United States in 2017 as a fixed combination with the antibiotic meropenem (Vabomere, The Medicines Company). Meropenem belongs to the carbapenems and beta-lactam antibiotics group. Structure and properties Vaborbactam (C12H16BNO5S, Mr = 297.1 g/mol) is a cyclic boron compound and a boronic acid derivative. It is not a representative … Vaborbactam
Products Tazobactam is commercially available as a fixed combination with piperacillin as an injectable (Tazobac, generics). It has been approved in many countries since 1992. In 2016, a combination with ceftolozane was released (Zerbaxa). Structure and properties Tazobactam (C10H12N4O5S, Mr = 300.3 g/mol) is a triazolylmethylpenicillic acid sulfone present in drugs as tazobactam sodium. Effects … Tazobactam
Products In many countries, no drugs containing sulbactam are commercially available. In other countries, injectables and tablets are available, usually as a fixed combination with the penicillin ampicillin. Structure and properties Sulbactam (C8H11NO5S, Mr = 233.2 g/mol) is present in drugs as sulbactam sodium. It is a penicillanic acid sulfone. Effects Sulbactam (ATC J01CG01) is … Sulbactam
Products Avibactam was approved in the United States in 2015, in the EU in 2016, and in many countries in 2019 in fixed combination with the cephalosporin ceftazidime as a powder for a concentrate for solution for infusion (Zavicefta). Structure and properties Avibactam (C7H11N3O6S, Mr = 265.25 g/mol), unlike other beta-lactamase inhibitors, is not itself … Avibactam
Products Clavulanic acid is sold exclusively in combinations with antibiotic amoxicillin. In addition to the original Augmentin, numerous generics are also available. Structure and properties Clavulanic acid (C8H9NO5, Mr = 199.16 g/mol) is present in drugs as potassium clavulanate, the potassium salt of clavulanic acid. Potassium clavulanate is a white, crystalline, hygroscopic powder that is … Clavulanic Acid
