Products Clopamide was commercially available in tablet form and exclusively in combination with other agents (Brinerdin, Viskaldix, off label). Structure and properties Clopamide (C14H20ClN3O3S, Mr = 345.8 g/mol) is a sulfonamide derivative. Effects Clopamide (ATC C03BA03) has diuretic and antihypertensive properties. It promotes excretion of water and sodium by inhibiting reabsorption. Indications In combination preparations: … Clopamide
Products Hydrochlorothiazide is commercially available in numerous antihypertensive agents in combination with ACE inhibitors, sartans, renin inhibitors, potassium-sparing diuretics, calcium channel blockers, and beta blockers. Use as a monopreparation (Esidrex) is less common. Hydrochlorothiazide has been approved in many countries since 1958. Structure and properties Hydrochlorothiazide (C7H8ClN3O4S2, Mr = 297.7 g/mol) is a white crystalline … Hydrochlorothiazide
Products Benzthiazide is no longer commercially available in many countries. It was formerly included in combination with triamterene in Dyrenium compositum. Structure and properties Benzthiazide (C15H14ClN3O4S3, Mr = 431.9 g/mol) Effects Benzthiazide has diuretic properties. Indications Edema Arterial hypertension
Products Butizide was marketed exclusively in combination with spironolactone in the form of film-coated tablets (Aldozone). It had been approved in many countries since 1968. Structure and properties Buticide (C11H16ClN3O4S2, Mr = 353.8 g/mol) Effects Buticide (ATC C03EA14) has diuretic properties. Indications In combination with spironolactone: Heart failure Liver cirrhosis with ascites and/or edema. Nephrotic … Buticide