Products Nafarelin is commercially available as a nasal spray (Synrelina). It has been approved in many countries since 1992. Structure and properties Nafarelin (C66H83N17O13, Mr = 1322.5 g/mol) is an agonist derivative and analog of gonadotropin-releasing hormone (GnRH). It is present in the drug as nafarelin acetate. It is a decapeptide that is administered nasally … Nafarelin
Products Gonadorelin is commercially available as an injectable (Lutrelef). It has been approved in many countries since 1983. Structure and properties Gonadorelin is a decapeptide. It is chemically and biologically identical to GnRH, which is released pulsatile by the hypothalamus. It is present in drugs as gonadorelin acetate, a white to slightly yellowish powder that … Gonadorelin
Products Goserelin is commercially available as a solid depot (Zoladex, generic). It has been approved in many countries since 1990. Structure and properties Goserelin is an analog of gonadotropin-releasing hormone (GnRH) and is present in drugs as goserelin acetate, a decapeptide and white powder that is soluble in water. Goserelin: Pyr-Glu-His-Trp-Ser-Tyr-D-Ser(But)-Leu-Arg-Pro-Azgly. GnRH: Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly Effects Goserelin … Goserelin
Products There are no human medicines containing buserelin on the market in many countries. Structure and properties Buserelin is a synthetic nonapeptide analogous to human gonadotropin-releasing hormone with agonistic activity for gonadorelin. Effects Buserelin (ATC L02AE01) is an analog of gonadotropin-releasing hormone (GnRH). Indications Endocrine treatment of advanced hormone-dependent prostate cancer, but not with prior … Buserelin
Products GnRH analogs are commercially available in many countries in the form of injectables, implants, and nasal sprays, among others. The first agent to be approved was goserelin (Zoladex) in 1990. Structure and properties GnRH analogs are synthetically produced derivatives of gonadotropin-releasing hormone (GnRH, LHRH) produced in the hypothalamus. GnRH is a decapeptide and has … GnRH Analogs
Products Triptorelin is commercially available as an injectable. It has been approved in many countries since 1995. Structure and properties Triptorelin is a more potent derivative of gonadotropin-releasing hormone (GnRH). At position 6, the amino acid glycine has been replaced by D-tryptophan. It is a decapeptide. GnRH: Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly. Triptorelin: Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly Effects Triptorelin (ATC L02AE04) is … Triptorelin
Products Leuprorelin is commercially available as an injectable and implant. It has been approved in many countries since 2004. Structure and properties Leuprorelin is present in drugs as leuprorelin acetate. The nonapeptide is a synthetic analog of the natural gonadotropin-releasing hormone GnRH. GnRH: Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly. Leuprorelin: 5-oxo-Pro-His-Trp-Ser-Tyr-D-Leu-Arg-N-ethyl-L-prolinamide Effects Leuprorelin (ATC L02AE02) inhibits the secretion of LH … Leuprorelin
Products Histrelin is commercially available as an implant (Vantas). It was approved in many countries in 2010. Structure and properties Histrelin is present in drugs as histrelin acetate. The nonapeptide is a synthetic analog of the natural gonadotropin-releasing hormone GnRH. Histrelin: 5-oxo-Pro-His-Trp-Ser-Tyr-Ntbenzyl-D-His-Leu-Arg-N-ethyl-L-prolinamide. GnRH: Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly Effects Histrelin (ATC H01CA03) blocks the release of LH and FSH … Histrelin
