Products Rilpivirine has been commercially available in the EU and the United States since 2011 in tablet form (Edurant, combination products). In many countries, rilpivirine was approved in February 2013. Structure and properties Rilpivirine (C22H18N6, Mr = 366.4 g/mol) has a non-nucleoside structure. It is a diarylpyrimidine and is present in drugs as rilpivirine hydrochloride, … Rilpivirine
Effects CCR5 antagonists have antiviral against HIV. They are selective antagonists of the interaction between human CCR5 and HIV-1 gp120, preventing viral entry the cells. Indications For treatment of HIV infection as part of combination antiretroviral therapy. Active ingredients Maraviroc (Celsentri) Detailed information.
Products Atazanavir is commercially available in capsule form (Reyataz). It has been approved in many countries since 2004. Generic versions were registered in 2017. Structure and properties Atazanavir (C38H52N6O7, Mr = 704.9 g/mol) is present in drugs as atazanavir sulfate, a white to slightly yellow crystalline powder that is sparingly soluble in water. Effects Atazanavir … Atazanavir
Products Ibalizumab was approved in the United States in 2018 and in the EU in 2019 (Trogarzo, TaiMed Biologics). Structure and properties Ibalizumab is a humanized IgG4 monoclonal antibody. It is produced by biotechnological methods. Unlike most antiviral agents, it is directed against an endogenous drug target rather than the virus. Effects Ibalizumab has antiviral … Ibalizumab
Products Fosamprenavir is commercially available in the form of film-coated tablets (Telzir). It has been approved in many countries since 2005. Structure and properties Fosamprenavir (C25H36N3O9PS, Mr = 585.6 g/mol) is present in drugs as fosamprenavir calcium. It is a prodrug that is rapidly biotransformed in the intestinal mucosa to the active metabolite amprenavir. Amprenavir … Fosamprenavir
Products Maraviroc is commercially available in the form of film-coated tablets (Celsentri, in some countries: Selzentry). It has been approved in many countries since 2008. Structure and properties Maraviroc (C29H41F2N5O, Mr = 513.7 g/mol) exists as a white to pale colored powder that is soluble in water. Effects Maraviroc (ATC J05AX09) has indirect antiviral properties. … Maraviroc
Products Tenofovir is commercially available in the form of film-coated tablets (Viread, combination products, generics). It has been approved in many countries since 2002. It is also used to treat chronic hepatitis B. This article refers to HIV. Structure and properties Tenofovir (C9H14N5O4P, Mr = 287.2 g/mol) is present in drugs in the form of … Tenofovir
Products Various drugs containing tenofoviralafenamide are on the market worldwide. In many countries, tenofoviralafenamide was first approved in 2016 (United States: 2015). Biktarvy: bictegravir, emtricitabine, and tenofoviralafenamide (HIV). Genvoya: elvitegravir, cobicistat, emtricitabine, and tenofoviralafenamide (HIV). Descovy: emtricitabine and tenofoviralafenamide (HIV). Odefsey: emtricitabine, rilpivirine and tenofoviralafenamide (HIV). Symtuza: darunavir + cobicistat + emtricitabine + tenofoviralafenamide. Vemlidy: … Tenofoviralafenamide
Products Lamivudine is commercially available as film-coated tablets and as an oral solution (3TC, generic, combination). It has been approved in many countries since 1996. Lamivudine is also administered for the treatment of chronic hepatitis B. This article refers to therapy for HIV. Generic medications are approved. Structure and Properties Lamivudine (C8H11N3O3S, Mr = 229.3 … Lamivudine
Products Saquinavir is commercially available in the form of film-coated tablets (Invirase). It has been approved in many countries since 1996 (United States: 1995). Structure and properties Saquinavir (C38H50N6O5, Mr = 670.8 g/mol) is present in the drug as saquinavir mesilate, a white, weakly hygroscopic powder that is practically insoluble in water. Effects Saquinavir (ATC … Saquinavir
Products Delavirdin is commercially available in the United States under the brand name Rescriptor. It is not commercially available in many countries. Structure and properties Delavirdine (C22H28N6O3S, Mr = 456.6 g/mol) Effects Delavirdine (ATC J05AG02) is antiviral and an inhibitor of HIV reverse transcriptase. Indications HIV
