Products Zalcitabine is not commercially available in many countries. Structure and properties Zalcitabine (C9H13N3O3, Mr = 211.2 g/mol) exists as a white crystalline powder that is soluble in water. Effects Zalcitabine (ATC J05AF03) is antiviral. It is an inhibitor of HIV reverse transcriptase. Indications HIV, combination antiretroviral therapy.
Products Nevirapine is commercially available in tablet and sustained-release tablet form (Viramune, generics). It has been approved in many countries since 1997. Structure and properties Nevirapine (C15H14N4O, Mr = 266.3 g/mol) exists as a white crystalline powder that is practically insoluble in water. It has a non-nucleoside structure. Effects Nevirapine (ATC J05AG01) has antiviral properties … Nevirapine
Products Nelfinavir was commercially available in the form of film-coated tablets (Viracept). It was approved in many countries in 1997 and withdrawn from the market in 2013 for commercial reasons. Structure and properties Nelfinavir (C32H45N3O4S, Mr = 567.8 g/mol) is present in the drug as nelfinavir mesilate, a white, amorphous powder that is sparingly soluble … Nelfinavir
Products Tipranavir is commercially available in capsule form (Aptivus). It has been approved in many countries since 2005. Structure and properties Tipranavir (C31H33F3N2O5S, Mr = 602.7 g/mol) exists as a white to slightly yellowish substance that is insoluble in an aqueous buffer at pH 7.5. Tipranavir has a nonpeptidic structure. Effects Tipranavir (ATC J05AE09) has … Tipranavir
Products Bictegravir was approved in the United States and EU in 2018 and in many countries in 2019 in fixed combination with emtricitabine and tenofoviralafenamide in the form of film-coated tablets (Biktarvy). Structure and properties Bictegravir (C21H18F3N3O5, Mr = 449.4 g/mol) exists as a white to yellowish substance. Effects Bictegravir (ATC J05AR20) has antiviral properties. … Bictegravir
Products Lopinavir is commercially available as film-coated tablets and as a syrup as a fixed combination with ritonavir (Kaletra). It has been approved in many countries since 2000. Structure and properties Lopinavir (C37H48N4O5, Mr = 628.8 g/mol) exists as a white to yellowish white powder that is practically insoluble in water. Effects Lopinavir (ATC J05AE06) … Lopinavir
Products Etravirine is commercially available in tablet form (Intelence). It has been approved in many countries since 2008. Structure and properties Etravirine (C20H15BrN6O, Mr = 435.3 g/mol) is a brominated aminopyrimidine and a benzonitrile derivative. It exists as a white to slightly yellow-brown powder and is practically insoluble in water. Etravirine has a non-nucleoside structure … Etravirine
Products Didanosine was commercially available in the form of capsules (Videx EC). It was first approved in 1991 as the second HIV drug after AZT (EC = enteric coated, capsules filled with enteric granules). Structure and properties Didanosine (C10H12N4O3, Mr = 236.2 g/mol) corresponds to 2′,3′-dideoxyinosine, a synthetic nucleoside analog of deoxyadenosine. The 3′-hydroxy group … Didanosine
Products Dolutegravir was approved in the United States and EU in 2013 in film-coated tablet form (Tivicay). It was registered in many countries in 2014. A fixed-dose combination with dolutegravir, abacavir, and lamivudine is also available (Triumeq). In 2017, a combination product with rilpivirine was launched in the US (Juluca). It was approved in the … Dolutegravir
Products Doravirin was approved in the US and EU in 2018 and in many countries in 2019 in film-coated tablet form (Pifeltro). It is also combined with lamivudine and tenofovirdisoproxil fixed (Delstrigo). Structure and properties Doravirin (C17H11ClF3N5O3, Mr = 425.8 g/mol) is a pyridinone and triazole derivative that is practically insoluble in water. The drug … Doravirin
Products Raltegravir is commercially available as film-coated tablets and chewable tablets (Isentress). It was approved in the United States in 2007 and in many countries in 2008 as the first integrase inhibitor. Structure and properties Raltegravir (C20H21FN6O5, Mr = 444.4 g/mol) is a hydroxypyrimidinone carboxamide. It is present in drugs in the form of the … Raltegravir
Products Most HIV protease inhibitors are commercially available in tablet or capsule form. In addition, a few liquid dosage forms are available for ingestion. Saquinavir (Invirase) was the first to be lanicized in 1995. Structure and properties The first HIV protease inhibitors were modeled on the natural peptide substrate of the HIV protease. The protease … HIV Protease Inhibitor
