Costimulation Inhibitors

Abatacept

Products Abatacept is commercially available as an injection and infusion preparation (Orencia). It was approved in the United States in 2005 and in the EU and many countries in 2007. Structure and properties Abatacept is a recombinant fusion protein with the following components: Extracellular domain of CTLA-4 (cytotoxic T-lymphocyte-associated protein 4). Modified Fc domain of … Abatacept

Belatacept

Products Belatacept was approved in many countries in 2011 as a powder for the preparation of an infusion solution concentrate (Nulojix). Structure and properties Belatacept is a soluble fusion protein consisting of a modified extracellular domain of human cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and a fragment of the Fc domain of a human IgG1 antibody. … Belatacept